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Angptl2
Gene Detail
 Symbol
Name
ID
Angptl2
angiopoietin-like 2
MGI:1347002
Synonyms Arp2
Feature Type protein coding gene
Genetic Map
Chromosome 2
22.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:33216069-33247717 bp, + strand
From VEGA annotation of GRCm38

  31649 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22695  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Angptl2

Human
homologs
Human Homolog ANGPTL2, angiopoietin-like 2
NCBI Gene ID 23452
neXtProt AC  NX_Q9UKU9
Human Synonyms  ARP2, HARP
Human Chr (Location)  9q34; chr9:127087349-127122794 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(3) Targeted(3)
Incidental mutations (data from APF )
 
When fed a high-fat diet, mice homozygous for a knock-out allele show decreased weight gain, reduced adipocity, a lower respiratory quotient, reduced inflammation in adipose tissues, enhanced glucose tolerance, and increased insulin sensitivity in both skeletal muscle and liver relative to controls.
 
Interactions
Angptl2 interacts with 281 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (2 annotations)
Component extracellular region, extracellular vesicular exosome
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (314)    Tissues (25)    Images (24)
Theiler Stages: 23
Assay TypeResults
RNA in situ 302
cDNA source data(76)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(77) cDNA(77)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000012579 (Evidence)
Ensembl Gene ModelENSMUSG00000004105 (Evidence)
Entrez Gene26360 (Evidence)
UniGene208919
DFCITC1580574, TC1595771, TC1614009, TC1625470, TC1679363, TC1701722
DoTSDT.101368609, DT.488236, DT.91312674, DT.91326167
NIA Mouse Gene IndexU042279
Consensus CDS ProjectCCDS15940.1
International Mouse Knockout Project StatusAngptl2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012579 VEGA Gene Model | MGI Sequence Detail 31649 C57BL/6J ±  kb
transcript OTTMUST00000029972 VEGA | MGI Sequence Detail 3339 Not Applicable 
polypeptide OTTMUSP00000013478 VEGA | MGI Sequence Detail 493 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(127 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
InterPro IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
InterPro IPR014715 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
InterPro IPR020837 Fibrinogen, conserved site
Protein Ontology PR:000004027 angiopoietin-related protein 2
References (Earliest) J:57564 Kim I, et al., Molecular cloning, expression, and characterization of angiopoietin-related protein. angiopoietin-related protein induces endothelial cell sprouting. J Biol Chem. 1999 Sep 10;274(37):26523-8
(Latest) J:206731 Aoi J, et al., Angiopoietin-like Protein 2 Accelerates Carcinogenesis by Activating Chronic Inflammation and Oxidative Stress. Mol Cancer Res. 2014 Feb;12(2):239-49
All references(37)
Other
accession IDs
MGI:2139009, MGI:2139338

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory