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Angptl2
Gene Detail
Symbol

Name
ID
Angptl2
angiopoietin-like 2
MGI:1347002
Synonyms
Arp2
Feature Type
protein coding gene
Genetic Map
Chromosome 2
22.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:33216069-33247717 bp, + strand
From VEGA annotation of GRCm38

  31649 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22695  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: ANGPTL2
Gene Tree: Angptl2

Human
homologs
ANGPTL2, angiopoietin-like 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 23452
neXtProt AC: NX_Q9UKU9

Human Synonyms: ARP2, HARP

Human Chr (Location): 9q34; chr9:127087349-127122797 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(3) Targeted(3)
Incidental mutations (data from APF , CvDC )
 
When fed a high-fat diet, mice homozygous for a knock-out allele show decreased weight gain, reduced adipocity, a lower respiratory quotient, reduced inflammation in adipose tissues, enhanced glucose tolerance, and increased insulin sensitivity in both skeletal muscle and liver relative to controls.
 
Interactions
Angptl2 interacts with 281 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (2 annotations)
Component extracellular exosome, extracellular region
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (314)    Tissues (25)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 314
cDNA source data(76)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA ANGPTL2 ; Xenbase angptl2 ; ZFIN angptl2b    NEW 
Molecular
reagents
All nucleic(77) cDNA(77)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000012579 (Evidence)
Ensembl Gene Model ENSMUSG00000004105 (Evidence)
Entrez Gene 26360 (Evidence)
UniGene 208919
DFCI TC1580574, TC1625470, TC1614009, TC1595771, TC1679363, TC1701722
DoTS DT.101368609, DT.91326167, DT.488236, DT.91312674
NIA Mouse Gene Index U042279
Consensus CDS Project CCDS15940.1
International Mouse Phenotyping Consortium Status Angptl2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012579 VEGA Gene Model | MGI Sequence Detail 31649 C57BL/6J ±  kb
transcript OTTMUST00000029972 VEGA | MGI Sequence Detail 3339 Not Applicable 
polypeptide OTTMUSP00000013478 VEGA | MGI Sequence Detail 493 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(127 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
InterPro IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
InterPro IPR014715 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
InterPro IPR020837 Fibrinogen, conserved site
Protein Ontology PR:000004027 angiopoietin-related protein 2
References
(Earliest) J:57564 Kim I, et al., Molecular cloning, expression, and characterization of angiopoietin-related protein. angiopoietin-related protein induces endothelial cell sprouting. J Biol Chem. 1999 Sep 10;274(37):26523-8
(Latest) J:206731 Aoi J, et al., Angiopoietin-like Protein 2 Accelerates Carcinogenesis by Activating Chronic Inflammation and Oxidative Stress. Mol Cancer Res. 2014 Feb;12(2):239-49
All references(37)
Other
accession IDs
MGI:2139009, MGI:2139338

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory