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Angptl2 Gene Detail
Summary
  • Symbol
    Angptl2
  • Name
    angiopoietin-like 2
  • Synonyms
    Arp2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347002
    NCBI Gene: 26360
  • Gene Overview
    MyGene.info: ANGPTL2
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:33216069-33247717 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 22.36 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    127 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347002
protein coding gene Chr2:33215951-33247725 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025632
protein coding gene Chr2:31730801-31762442 (+)
A/J MGP_AJ_G0025609
protein coding gene Chr2:30377150-30408800 (+)
AKR/J MGP_AKRJ_G0025579
protein coding gene Chr2:31457208-31490235 (+)
BALB/cJ MGP_BALBcJ_G0025606
protein coding gene Chr2:30497086-30528736 (+)
C3H/HeJ MGP_C3HHeJ_G0025366
protein coding gene Chr2:31350053-31381703 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026050
protein coding gene Chr2:32670536-32702196 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023459
protein coding gene Chr2:29106524-29138360 (+)
CAST/EiJ MGP_CASTEiJ_G0024828
protein coding gene Chr2:31316403-31348032 (+)
CBA/J MGP_CBAJ_G0025344
protein coding gene Chr2:33917736-33949384 (+)
DBA/2J MGP_DBA2J_G0025477
protein coding gene Chr2:30139752-30171392 (+)
FVB/NJ MGP_FVBNJ_G0025439
protein coding gene Chr2:30034445-30066341 (+)
LP/J MGP_LPJ_G0025563
protein coding gene Chr2:31615349-31647250 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025470
protein coding gene Chr2:33519543-33551202 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026108
protein coding gene Chr2:31345674-31377288 (+)
PWK/PhJ MGP_PWKPhJ_G0024576
protein coding gene Chr2:30055357-30087527 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024376
protein coding gene Chr2:31504056-31537246 (+)
WSB/EiJ MGP_WSBEiJ_G0024897
protein coding gene Chr2:31528072-31559720 (+)



Homology
more
  • Human Ortholog
    ANGPTL2, angiopoietin like 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ANGPTL2, angiopoietin like 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARP2, HARP
  • Links
    NCBI Gene ID: 23452
    neXtProt AC: NX_Q9UKU9
    UniProt: Q9UKU9

  • Chr Location
    9q33.3; chr9:127087349-127122803 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Angptl2 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 3 alleles in 3 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
When fed a high-fat diet, mice homozygous for a knock-out allele show decreased weight gain, reduced adipocity, a lower respiratory quotient, reduced inflammation in adipose tissues, enhanced glucose tolerance, and increased insulin sensitivity in both skeletal muscle and liver relative to controls.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000004105 Ensembl Gene Model | MGI Sequence Detail 31649 C57BL/6J ±  kb
    transcript ENSMUST00000004208 Ensembl | MGI Sequence Detail 3339 Not Applicable  
    polypeptide ENSMUSP00000004208 Ensembl | MGI Sequence Detail 493 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000004027 angiopoietin-related protein 2
    • InterPro Domains
      IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
      IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
      IPR020837 Fibrinogen, conserved site
      IPR036056 Fibrinogen-like, C-terminal
    Molecular
    Reagents
    less
    • All nucleic 78
      cDNA 78

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2139009, MGI:2139338
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 2
      Phenotypes 18
    • Earliest
      J:57564 Kim I, et al., Molecular cloning, expression, and characterization of angiopoietin-related protein. angiopoietin-related protein induces endothelial cell sprouting. J Biol Chem. 1999 Sep 10;274(37):26523-8
    • Latest
      J:240177 Horiguchi H, et al., ANGPTL2 expression in the intestinal stem cell niche controls epithelial regeneration and homeostasis. EMBO J. 2017 Feb 15;36(4):409-424

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory