Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes AIRE
  • Mouse genes Aire
  • Rat genes Aire
  • Zfish genes aire
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Aire

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	AIRE	IDA		Human	PMID:18292755
Molecular Function	GO:0042393	histone binding	AIRE	IDA		Human	PMID:18292755
Molecular Function	GO:0042393	histone binding	AIRE	IDA		Human	PMID:19446523
Molecular Function	GO:0042802	identical protein binding	AIRE	IPI	UniProtKB:O43918	Human	PMID:15712268
Molecular Function	GO:0042802	identical protein binding	AIRE	IPI	UniProtKB:O43918	Human	PMID:20185822
Molecular Function	GO:0042802	identical protein binding	AIRE	IPI	UniProtKB:O43918	Human	PMID:28540407
Molecular Function	GO:0042802	identical protein binding	Aire	IPI	UniProtKB:Q9Z0E3	Mouse	MGI:MGI:5294312|PMID:11533054
Molecular Function	GO:0005515	protein binding	AIRE	IPI	UniProtKB:P16333	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	AIRE	IPI	UniProtKB:P68431	Human	PMID:18292755
Molecular Function	GO:0005515	protein binding	AIRE	IPI	UniProtKB:P78527	Human	PMID:20085707
Molecular Function	GO:0005515	protein binding	AIRE	IPI	UniProtKB:Q9UER7	Human	PMID:20185822
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	AIRE	IDA		Human	PMID:11533054
Molecular Function	GO:0008270	zinc ion binding	AIRE	IDA		Human	PMID:19446523
Cellular Component	GO:0005737	cytoplasm	Aire	IDA		Mouse	PMID:11156688
Cellular Component	GO:0001674	female germ cell nucleus	Aire	IDA		Mouse	PMID:11156688
Cellular Component	GO:0005622	intracellular anatomical structure	Aire	IDA		Mouse	PMID:17599412
Cellular Component	GO:0001673	male germ cell nucleus	Aire	IDA		Mouse	PMID:11156688
Cellular Component	GO:0016604	nuclear body	Aire	IDA		Mouse	MGI:MGI:3818193|PMID:19015306
Cellular Component	GO:0005634	nucleus	Aire	IDA		Mouse	PMID:11156688
Cellular Component	GO:0005634	nucleus	Aire	IDA		Mouse	PMID:11854172
Biological Process	GO:0002509	central tolerance induction to self antigen	AIRE	IMP		Human	PMID:26084028
Biological Process	GO:0006959	humoral immune response	Aire	IMP	MGI:MGI:2182940	Mouse	PMID:11854172
Biological Process	GO:0045060	negative thymic T cell selection	Aire	IGI	MGI:MGI:1277186	Mouse	PMID:23382543
Biological Process	GO:0002458	peripheral T cell tolerance induction	Aire	IDA		Mouse	MGI:MGI:5562496|PMID:23993652
Biological Process	GO:0032722	positive regulation of chemokine production	Aire	IMP		Mouse	MGI:MGI:4430981|PMID:19923453
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	AIRE	IDA		Human	PMID:18292755
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	AIRE	IMP		Human	PMID:26084028
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	AIRE	IMP		Human	PMID:11274163
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Aire	IDA		Mouse	PMID:17599412
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Aire	IMP	MGI:MGI:3722595	Mouse	PMID:17599412
Biological Process	GO:0006355	regulation of DNA-templated transcription	AIRE	IDA		Human	PMID:18292755
Biological Process	GO:2000410	regulation of thymocyte migration	Aire	IMP		Mouse	MGI:MGI:4430981|PMID:19923453
Biological Process	GO:0097536	thymus epithelium morphogenesis	Aire	IMP		Mouse	MGI:MGI:3818193|PMID:19015306
Biological Process	GO:0006366	transcription by RNA polymerase II	Aire	IMP	MGI:MGI:3722595	Mouse	PMID:17599412

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern