Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes AFF2
  • Mouse genes Aff2
  • Rat genes Aff2
  • Zfish genes aff2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Aff2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0002151	G-quadruplex RNA binding	Aff2	IDA		Mouse	MGI:MGI:4430801|PMID:19136466
Molecular Function	GO:0005515	protein binding	AFF2	IPI	UniProtKB:O00629	Human	PMID:35044719
Cellular Component	GO:0016607	nuclear speck	AFF2	IDA		Human	PMID:19136466
Cellular Component	GO:0016607	nuclear speck	Aff2	IDA		Mouse	MGI:MGI:4430801|PMID:19136466
Cellular Component	GO:0016607	nuclear speck	Aff2	IDA		Mouse	PMID:26013685
Cellular Component	GO:0005634	nucleus	Aff2	IDA		Mouse	PMID:26013685
Biological Process	GO:0007611	learning or memory	Aff2	IMP	MGI:MGI:2182641	Mouse	PMID:11923441
Biological Process	GO:0010629	negative regulation of gene expression	Aff2	IMP		Mouse	PMID:23562910
Biological Process	GO:0035063	nuclear speck organization	AFF2	IMP		Human	PMID:23562910
Biological Process	GO:0010468	regulation of gene expression	AFF2	IMP		Human	PMID:23562910
Biological Process	GO:0043484	regulation of RNA splicing	AFF2	IMP		Human	PMID:19136466
Biological Process	GO:0043484	regulation of RNA splicing	Aff2	IDA		Mouse	MGI:MGI:4430801|PMID:19136466

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern