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Aff2 Gene Detail
Summary
  • Symbol
    Aff2
  • Name
    AF4/FMR2 family, member 2
  • Synonyms
    Fmr2, Ox19, Oxh
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202294
    NCBI Gene: 14266
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:68403900-68911643 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome X, 35.53 cM, cytoband A5
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1999 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1202294
protein coding gene ChrX:68403796-68915660 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035774
protein coding gene ChrX:64981656-65487592 (+)
A/J MGP_AJ_G0035757
protein coding gene ChrX:65100066-65628126 (+)
AKR/J MGP_AKRJ_G0035679
protein coding gene ChrX:66870796-67407169 (+)
BALB/cJ MGP_BALBcJ_G0035744
protein coding gene ChrX:64320041-64822019 (+)
C3H/HeJ MGP_C3HHeJ_G0035448
protein coding gene ChrX:65416033-65934987 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036274
protein coding gene ChrX:66942340-67471188 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033123
protein coding gene ChrX:64087573-64570606 (+)
CAST/EiJ MGP_CASTEiJ_G0034739
protein coding gene ChrX:50907569-51411243 (+)
CBA/J MGP_CBAJ_G0035422
protein coding gene ChrX:68767456-69319484 (+)
DBA/2J MGP_DBA2J_G0035575
protein coding gene ChrX:64662756-65156340 (+)
FVB/NJ MGP_FVBNJ_G0035526
protein coding gene ChrX:64127542-64619116 (+)
LP/J MGP_LPJ_G0035663
protein coding gene ChrX:65769005-66265530 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035561
protein coding gene ChrX:71224538-71816737 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036295
protein coding gene ChrX:64797983-65319213 (+)
PWK/PhJ MGP_PWKPhJ_G0034439
protein coding gene ChrX:49054624-49545401 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034278
protein coding gene ChrX:51881169-52390175 (+)
WSB/EiJ MGP_WSBEiJ_G0034882
protein coding gene ChrX:64152116-64654496 (+)



Homology
more
  • Human Ortholog
    AFF2, ALF transcription elongation factor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AFF2, ALF transcription elongation factor 2
  • Synonyms
    FMR2, FMR2P, FRAXE, MRX2, OX19, XLID109
  • Links
    NCBI Gene ID: 2334
    neXtProt AC: NX_P51816
    UniProt: P51816

  • Chr Location
    Xq28; chrX:148500617-149000663 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with human AFF2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit impaired conditioned fear responses and enhanced long-term potentiation in hippocampal slices.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031189 Ensembl Gene Model | MGI Sequence Detail 507744 C57BL/6J ±  kb
    transcript ENSMUST00000033532 Ensembl | MGI Sequence Detail 4523 Not Applicable  
    polypeptide ENSMUSP00000033532 Ensembl | MGI Sequence Detail 1272 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 13
      Primer pair 5
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-35041, MGI:106585
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 10
      Gene Ontology 7
      Phenotypes 6
    • Earliest
      J:31280 Chakrabarti L, et al., A candidate gene for mild mental handicap at the FRAXE fragile site. Hum Mol Genet. 1996 Feb;5(2):275-82
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory