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Aff2
Gene Detail
 Symbol
Name
ID
Aff2
AF4/FMR2 family, member 2
MGI:1202294
Synonyms Fmr2, Ox19, Oxh
Feature Type protein coding gene
Genetic Map
Chromosome X
35.53 cM, cytoband A5
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
ChrX:69360294-69868037 bp, + strand
From VEGA annotation of GRCm38

  507744 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1532  Vertebrate Homology Class
1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Gene Tree: Aff2

Alleles
and
phenotypes
All alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit impaired conditioned fear responses and enhanced long-term potentiation in hippocampal slices.
 
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process learning or memory, mRNA processing, ...
Component nuclear speck, nucleus
Function G-quadruplex RNA binding, RNA binding
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (216)    Tissues (190)    Images (22)
Theiler Stages: 10, 17, 18, 19, 20, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 163
In situ reporter (knock in) 32
Northern blot 19
RT-PCR 2
cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(15) cDNA(11) Primer pair(4)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000017765 (Evidence)
Ensembl Gene ModelENSMUSG00000031189 (Evidence)
Entrez Gene14266 (Evidence)
DFCITC1589590, TC1651424, TC1706767
DoTSDT.55281809, DT.91334146, DT.91338205, DT.99847431
NIA Mouse Gene IndexU019904
Consensus CDS ProjectCCDS30173.1
International Mouse Knockout Project StatusAff2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017765 VEGA Gene Model | MGI Sequence Detail 507744 C57BL/6J ±  kb
transcript OTTMUST00000043020 VEGA | MGI Sequence Detail 4523 Not Applicable 
polypeptide OTTMUSP00000019340 VEGA | MGI Sequence Detail 1272 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(14) UniProt(3)
Polymorphisms SNPs within 2kb(2014 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007797 Transcription factor AF4/FMR2
Protein Ontology PR:000032758 AF4/FMR2 family member 2
References (Earliest) J:31280 Chakrabarti L, et al., A candidate gene for mild mental handicap at the FRAXE fragile site. Hum Mol Genet. 1996 Feb;5(2):275-82
(Latest) J:198533 Melko M, et al., Loss of FMR2 further emphasizes the link between deregulation of immediate early response genes FOS and JUN and intellectual disability. Hum Mol Genet. 2013 Aug 1;22(15):2984-91
All references(34)
Other
accession IDs
MGD-MRK-35041, MGI:106585

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory