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Aff2 Gene Detail
Summary
  • Symbol
    Aff2
  • Name
    AF4/FMR2 family, member 2
  • Synonyms
    Fmr2, Ox19, Oxh
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202294
    NCBI Gene: 14266
  • Gene Overview
    MyGene.info: AFF2
  • Alliance
Location & Maps
more
  • Sequence Map
    ChrX:69360294-69868037 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      507744 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 35.53 cM, cytoband A5
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    AFF2, AF4/FMR2 family member 2
  • Vertebrate Orthologs
    5
  • Human Ortholog
    AFF2, AF4/FMR2 family member 2
    Orthology source: HGNC
  • Synonyms
    FMR2, FMR2P, FRAXE, MRX2, OX19
  • Links
    NCBI Gene ID: 2334
    neXtProt AC: NX_P51816
    UniProt: P51816

  • Chr Location
    Xq28; chrX:148500619-149000663 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    1 phenotype reference
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit impaired conditioned fear responses and enhanced long-term potentiation in hippocampal slices.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000017765 VEGA Gene Model | MGI Sequence Detail 507744 C57BL/6J ±  kb
    transcript OTTMUST00000043020 VEGA | MGI Sequence Detail 4523 Not Applicable  
    polypeptide OTTMUSP00000019340 VEGA | MGI Sequence Detail 1272 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      2004 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 11
      Primer pair 4
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-35041, MGI:106585
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 9
      Gene Ontology 5
      Phenotypes 1
    • Earliest
      J:31280 Chakrabarti L, et al., A candidate gene for mild mental handicap at the FRAXE fragile site. Hum Mol Genet. 1996 Feb;5(2):275-82
    • Latest
      J:243218 Hooper JE, et al., Systems biology of facial development: contributions of ectoderm and mesenchyme. Dev Biol. 2017 Jun 01;426(1):97-114

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/08/2018
    MGI 6.12
    The Jackson Laboratory