Aff2
Gene Detail

Symbol Name ID

Aff2 AF4/FMR2 family, member 2 MGI:1202294

Synonyms

Fmr2, Ox19, Oxh

Feature Type

protein coding gene

Genetic Map

Chromosome X

35.53 cM, cytoband A5
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

ChrX:69360294-69868037 bp, + strand From VEGA annotation of GRCm38   507744 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1532  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Aff2

Human homologs

Human Homolog		AFF2, AF4/FMR2 family, member 2
NCBI Gene ID		2334
neXtProt AC		NX_P51816
Human Synonyms		FMR2, FMR2P, FRAXE, MRX2, OX19
Human Chr (Location)		Xq28; chrX:147582139-148082193 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human AFF2

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Homozygotes for a targeted null mutation exhibit impaired conditioned fear responses and enhanced long-term potentiation in hippocampal slices.

 

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	learning or memory, mRNA processing, ...
Component	nuclear speck, nucleus
Function	G-quadruplex RNA binding, RNA binding

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (216)    Tissues (190)    Images (22)
Theiler Stages: 10, 17, 18, 19, 20, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	163
In situ reporter (knock in)	32
Northern blot	19
RT-PCR	2

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(15) cDNA(11) Primer pair(4)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000017765 (Evidence)
Ensembl Gene Model	ENSMUSG00000031189 (Evidence)
Entrez Gene	14266 (Evidence)
DFCI	TC1589590, TC1651424, TC1706767
DoTS	DT.55281809, DT.91334146, DT.91338205, DT.99847431
NIA Mouse Gene Index	U019904
Consensus CDS Project	CCDS30173.1
International Mouse Knockout Project Status	Aff2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017765	VEGA Gene Model | MGI Sequence Detail	507744	C57BL/6J
transcript	OTTMUST00000043020	VEGA | MGI Sequence Detail	4523	Not Applicable
polypeptide	OTTMUSP00000019340	VEGA | MGI Sequence Detail	1272	Not Applicable

All sequences(34) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(1900 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007797	Transcription factor AF4/FMR2
Protein Ontology	PR:000032758	AF4/FMR2 family member 2

References

(Earliest) J:31280 Chakrabarti L, et al., A candidate gene for mild mental handicap at the FRAXE fragile site. Hum Mol Genet. 1996 Feb;5(2):275-82
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(34)

Other accession IDs

MGD-MRK-35041, MGI:106585