Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ACTN2
  • Mouse genes Actn2
  • Rat genes Actn2
  • Zfish genes actn2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Actn2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051015	actin filament binding	Actn2	IDA		Mouse	PMID:15465019
Molecular Function	GO:0008092	cytoskeletal protein binding	ACTN2	IDA		Human	PMID:10427098
Molecular Function	GO:0008092	cytoskeletal protein binding	ACTN2	IDA		Human	PMID:11699871
Molecular Function	GO:0008092	cytoskeletal protein binding	Actn2	IDA		Mouse	MGI:MGI:1340723|PMID:10391924
Molecular Function	GO:0051373	FATZ binding	ACTN2	IDA		Human	PMID:11699871
Molecular Function	GO:0042802	identical protein binding	ACTN2	IPI	UniProtKB:P35609	Human	PMID:11101506
Molecular Function	GO:0042802	identical protein binding	ACTN2	IPI	UniProtKB:P35609	Human	PMID:25416956
Molecular Function	GO:0042802	identical protein binding	ACTN2	IPI	UniProtKB:P35609	Human	PMID:25433700
Molecular Function	GO:0042802	identical protein binding	ACTN2	IPI	UniProtKB:P35609	Human	PMID:25502805
Molecular Function	GO:0042802	identical protein binding	ACTN2	IPI	UniProtKB:P35609	Human	PMID:31515488
Molecular Function	GO:0042802	identical protein binding	ACTN2	IPI	UniProtKB:P35609	Human	PMID:9501083
Molecular Function	GO:0030274	LIM domain binding	Actn2	IPI	PR:Q9JKS4-6	Mouse	PMID:10391924
Molecular Function	GO:0030274	LIM domain binding	Actn2	IPI	PR:Q9JKS4-1	Mouse	PMID:10391924
Molecular Function	GO:0030374	nuclear receptor coactivator activity	Actn2	IDA		Mouse	PMID:15072553
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	ACTN2	IDA		Human	PMID:25433700
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:O75112	Human	PMID:10427098
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q61824	Human	PMID:10788519
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:P22460	Human	PMID:10812072
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:O00151	Human	PMID:10861853
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q8WZ42	Human	PMID:11101506
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q86TC9	Human	PMID:11309420
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:P22460	Human	PMID:11389904
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q9NP98	Human	PMID:11842093
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q9NPC6	Human	PMID:11842093
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q8WZ42	Human	PMID:11846417
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q9Y3A2	Human	PMID:12559088
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q9Y561	Human	PMID:12809483
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q9NRI5	Human	PMID:12812986
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:P50461	Human	PMID:15205937
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q86VF7	Human	PMID:15205937
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:P03950	Human	PMID:15737636
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q8N3V7-3	Human	PMID:15841212
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q8WZ42	Human	PMID:16902413
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q9H2S1	Human	PMID:19815520
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q03001-1	Human	PMID:19932097
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q53GG5	Human	PMID:23414517
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q8WZ42	Human	PMID:23414517
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:P50461	Human	PMID:24860983
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:O95863	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:P00540	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:P23497	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q14D33	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q53GG5	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q5PSV4	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q8IY33	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q8IYX7	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q9NPC6	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:J3KMY6	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:O43827	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:O60232	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:P05496	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:P12814	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:P23497-2	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:P23771	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:P26842	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:P29373	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:P30711	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:P47897	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:P49458	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:P62140	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:P62805	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:P63244	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:P78560	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q15506	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q53GG5-2	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q7Z5G4	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q7Z7H8	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q8IYT4	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q8IYX7	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q8WW35	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q8WXI8	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q9H0E2	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q9NPC6	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q9Y247	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:A0A0S2Z4Y0	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q9UBF9	Human	PMID:26871637
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q9NRI5	Human	PMID:31413325
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:O95863	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:P23497	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q14D33	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q53GG5	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q5PSV4	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q8IY33	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q8IYX7	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q9NPC6	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:A8MYP8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:O75604	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:O95059	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:O95863	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:P25786	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:P28222	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q14D33	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q53FD0-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q5PSV4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q6ZUT1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q8IVT4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q8IY33	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q8NE01	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q92934	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q96HA8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q9H987-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	ACTN2	IPI	UniProtKB:Q8WZ42	Human	PMID:9501083
Molecular Function	GO:0005515	protein binding	Actn2	IPI	UniProtKB:P11798	Mouse	MGI:MGI:5508263|PMID:16120608
Molecular Function	GO:0005515	protein binding	Actn2	IPI	UniProtKB:Q01097	Mouse	MGI:MGI:3701026|PMID:16710293
Molecular Function	GO:0005515	protein binding	Actn2	IPI	UniProtKB:Q01097	Mouse	MGI:MGI:1860431|PMID:10862698
Molecular Function	GO:0005515	protein binding	Actn2	IPI	UniProtKB:Q9JKS4	Mouse	MGI:MGI:1340723|PMID:10391924
Molecular Function	GO:0005515	protein binding	Actn2	IPI	UniProtKB:Q91ZU6	Mouse	PMID:19932097
Molecular Function	GO:0005515	protein binding	Actn2	IPI	MGI:MGI:1916010	Mouse	PMID:20215401
Molecular Function	GO:0005515	protein binding	Actn2	IPI	PR:Q61026	Mouse	PMID:15072553
Molecular Function	GO:0005515	protein binding	Actn2	IPI	PR:Q9JK37	Mouse	PMID:11114196
Molecular Function	GO:0005515	protein binding	Actn2	IPI	PR:Q9JJW5	Mouse	PMID:11114196
Molecular Function	GO:0005515	protein binding	Actn2	IPI	PR:Q8K4E0	Mouse	PMID:22693585
Molecular Function	GO:0005515	protein binding	Actn2	IPI	PR:Q70KF4	Mouse	PMID:16407236
Molecular Function	GO:0005515	protein binding	Actn2	IPI	UniProtKB:P36202	Rat	PMID:15456832|RGD:13432260
Molecular Function	GO:0005515	protein binding	Actn2	IPI	RGD:1359203	Rat	PMID:15505042|RGD:1359754
Molecular Function	GO:0005515	protein binding	Actn2	IPI	RGD:1559992	Rat	PMID:15843396|RGD:7175289
Molecular Function	GO:0019904	protein domain specific binding	ACTN2	IPI	UniProtKB:Q9H2S1	Human	PMID:19815520
Molecular Function	GO:0031432	titin binding	ACTN2	IPI	UniProtKB:Q8WZ42	Human	PMID:11846417
Molecular Function	GO:0031432	titin binding	ACTN2	IPI	UniProtKB:Q8WZ42	Human	PMID:9501083
Molecular Function	GO:0070080	titin Z domain binding	ACTN2	IPI	UniProtKB:Q8WZ42	Human	PMID:11846417
Molecular Function	GO:0070080	titin Z domain binding	ACTN2	IMP		Human	PMID:25433700
Molecular Function	GO:0044325	transmembrane transporter binding	ACTN2	IPI	UniProtKB:P22460	Human	PMID:10812072
Molecular Function	GO:0044325	transmembrane transporter binding	ACTN2	IPI	UniProtKB:Q01668	Human	PMID:17110593
Molecular Function	GO:0044325	transmembrane transporter binding	ACTN2	IPI	UniProtKB:Q13936	Human	PMID:17110593
Molecular Function	GO:0044325	transmembrane transporter binding	ACTN2	IPI	UniProtKB:Q9H2S1	Human	PMID:17110593
Molecular Function	GO:0044325	transmembrane transporter binding	ACTN2	IPI	UniProtKB:Q9P0L9	Human	PMID:17944866
Molecular Function	GO:0044325	transmembrane transporter binding	ACTN2	IPI	UniProtKB:Q14524	Human	PMID:19943616
Molecular Function	GO:0044325	transmembrane transporter binding	Actn2	IPI	UniProtKB:Q9JJV9	Mouse	MGI:MGI:5640949|PMID:19943616
Cellular Component	GO:0030864	cortical actin cytoskeleton	Actn2	IDA		Rat	PMID:15505042|RGD:1359754
Cellular Component	GO:0070062	extracellular exosome	ACTN2	HDA		Human	PMID:23533145
Cellular Component	GO:0030175	filopodium	ACTN2	IDA		Human	PMID:12356918
Cellular Component	GO:0005925	focal adhesion	ACTN2	IMP		Human	PMID:16807302
Cellular Component	GO:0098978	glutamatergic synapse	Actn2	IDA		Rat	PMID:9454847|RGD:13702332
Cellular Component	GO:0005886	plasma membrane	ACTN2	IDA		Human	PMID:19815520
Cellular Component	GO:0098871	postsynaptic actin cytoskeleton	Actn2	IDA		Rat	PMID:9454847|RGD:13702332
Cellular Component	GO:0098839	postsynaptic density membrane	Actn2	IDA		Rat	PMID:9454847|RGD:13702332
Cellular Component	GO:0099092	postsynaptic density, intracellular component	Actn2	IDA		Rat	PMID:9454847|RGD:13702332
Cellular Component	GO:0030017	sarcomere	Actn2	IDA		Mouse	PMID:24840128
Cellular Component	GO:0030017	sarcomere	Actn2	IDA		Mouse	PMID:16585392
Cellular Component	GO:0030018	Z disc	ACTN2	IDA		Human	PMID:19932097
Cellular Component	GO:0030018	Z disc	ACTN2	IDA		Human	PMID:19943616
Cellular Component	GO:0030018	Z disc	ACTN2	IDA		Human	PMID:25433700
Cellular Component	GO:0030018	Z disc	Actn2	IDA		Mouse	MGI:MGI:6102963|PMID:29206857
Cellular Component	GO:0030018	Z disc	Actn2	IDA		Mouse	MGI:MGI:4366185|PMID:19815520
Cellular Component	GO:0030018	Z disc	Actn2	IDA		Mouse	MGI:MGI:4421360|PMID:19932097
Cellular Component	GO:0030018	Z disc	Actn2	IDA		Mouse	MGI:MGI:3771286|PMID:17110593
Cellular Component	GO:0030018	Z disc	Actn2	IDA		Mouse	PMID:17360664
Cellular Component	GO:0030018	Z disc	Actn2	IDA		Mouse	PMID:16407236
Cellular Component	GO:0030018	Z disc	Actn2	IDA		Mouse	PMID:18761673
Cellular Component	GO:0030018	Z disc	Actn2	IDA		Mouse	PMID:15665106
Cellular Component	GO:0030018	Z disc	Actn2	IDA		Mouse	PMID:20368620
Cellular Component	GO:0030018	Z disc	Actn2	IDA		Mouse	PMID:20215401
Biological Process	GO:0051695	actin filament uncapping	ACTN2	IMP		Human	PMID:25433700
Biological Process	GO:0055013	cardiac muscle cell development	Actn2	IMP		Mouse	MGI:MGI:4366185|PMID:19815520
Biological Process	GO:0001654	eye development	actn2b	IMP	ZFIN:ZDB-MRPHLNO-120524-7	Zfish	PMID:22253474
Biological Process	GO:0048041	focal adhesion assembly	ACTN2	IMP		Human	PMID:16807302
Biological Process	GO:0007507	heart development	actn2b	IMP	ZFIN:ZDB-MRPHLNO-120524-7	Zfish	PMID:22253474
Biological Process	GO:0030035	microspike assembly	ACTN2	IDA		Human	PMID:12356918
Biological Process	GO:0030239	myofibril assembly	actn2b	IMP	ZFIN:ZDB-MRPHLNO-120524-7	Zfish	PMID:22253474
Biological Process	GO:1901017	negative regulation of potassium ion transmembrane transporter activity	ACTN2	IMP		Human	PMID:10812072
Biological Process	GO:0043267	negative regulation of potassium ion transport	ACTN2	IMP		Human	PMID:10812072
Biological Process	GO:2000009	negative regulation of protein localization to cell surface	ACTN2	IMP		Human	PMID:10812072
Biological Process	GO:0086097	phospholipase C-activating angiotensin-activated signaling pathway	ACTN2	IMP		Human	PMID:25433700
Biological Process	GO:2001259	positive regulation of cation channel activity	ACTN2	IMP		Human	PMID:19815520
Biological Process	GO:2001259	positive regulation of cation channel activity	ACTN2	IMP		Human	PMID:19943616
Biological Process	GO:2001259	positive regulation of cation channel activity	Actn2	IMP		Mouse	MGI:MGI:4366185|PMID:19815520
Biological Process	GO:2001137	positive regulation of endocytic recycling	ACTN2	IMP		Human	PMID:19815520
Biological Process	GO:2001137	positive regulation of endocytic recycling	Actn2	IMP		Mouse	MGI:MGI:4366185|PMID:19815520
Biological Process	GO:1901018	positive regulation of potassium ion transmembrane transporter activity	ACTN2	IDA		Human	PMID:17110593
Biological Process	GO:0043268	positive regulation of potassium ion transport	ACTN2	IDA		Human	PMID:17110593
Biological Process	GO:0072659	protein localization to plasma membrane	ACTN2	IMP		Human	PMID:19815520
Biological Process	GO:0072659	protein localization to plasma membrane	ACTN2	IMP		Human	PMID:19943616
Biological Process	GO:0072659	protein localization to plasma membrane	Actn2	IMP		Mouse	MGI:MGI:4366185|PMID:19815520
Biological Process	GO:0042391	regulation of membrane potential	ACTN2	IMP		Human	PMID:10812072
Biological Process	GO:0045214	sarcomere organization	ACTN2	IMP		Human	PMID:25433700
Biological Process	GO:0045214	sarcomere organization	actn2b	IMP	ZFIN:ZDB-MRPHLNO-120524-7	Zfish	PMID:22253474
Biological Process	GO:0045214	sarcomere organization	actn2b	IMP	ZFIN:ZDB-MRPHLNO-121120-4	Zfish	PMID:22767232
Biological Process	GO:0048741	skeletal muscle fiber development	actn2b	IMP	ZFIN:ZDB-MRPHLNO-120524-7	Zfish	PMID:22253474

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern