Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes AAK1
  • Mouse genes Aak1
  • Rat genes Aak1
  • Zfish genes aak1a,aak1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Aak1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0035612	AP-2 adaptor complex binding	AAK1	IDA		Human	PMID:17494869
Molecular Function	GO:0035612	AP-2 adaptor complex binding	Aak1	IDA		Rat	PMID:11877461|RGD:8553925
Molecular Function	GO:0005112	Notch binding	AAK1	IDA		Human	PMID:21464124
Molecular Function	GO:0005515	protein binding	AAK1	IPI	UniProtKB:Q9NQ11	Human	PMID:22645275
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Aak1	IDA		Rat	PMID:11877461|RGD:8553925
Cellular Component	GO:0044305	calyx of Held	Aak1	EXP		Rat	PMID:33376223|RGD:155230702
Cellular Component	GO:0044305	calyx of Held	Aak1	IDA		Rat	PMID:33376223|RGD:155230702
Cellular Component	GO:0031252	cell leading edge	Aak1	IDA		Rat	PMID:11877461|RGD:8553925
Cellular Component	GO:0071439	clathrin complex	Aak1	IDA		Rat	PMID:11877461|RGD:8553925
Cellular Component	GO:0098793	presynapse	Aak1	IDA		Mouse	MGI:MGI:7316615|PMID:33376223
Cellular Component	GO:0098793	presynapse	Aak1	IDA		Rat	PMID:11877461|RGD:8553925
Cellular Component	GO:0045202	synapse	Aak1	IDA		Mouse	MGI:MGI:7316615|PMID:33376223
Cellular Component	GO:0043195	terminal bouton	Aak1	IDA		Rat	PMID:11877461|RGD:8553925
Biological Process	GO:0045747	positive regulation of Notch signaling pathway	AAK1	IDA		Human	PMID:21464124
Biological Process	GO:0140238	presynaptic endocytosis	Aak1	IDA		Mouse	PMID:33376223
Biological Process	GO:0140238	presynaptic endocytosis	Aak1	IMP		Mouse	PMID:33376223
Biological Process	GO:0140238	presynaptic endocytosis	Aak1	EXP		Rat	PMID:33376223|RGD:155230702
Biological Process	GO:0140238	presynaptic endocytosis	Aak1	IDA		Rat	PMID:33376223|RGD:155230702
Biological Process	GO:0046777	protein autophosphorylation	Aak1	IDA		Rat	PMID:11877461|RGD:8553925
Biological Process	GO:0006468	protein phosphorylation	AAK1	IDA		Human	PMID:17494869
Biological Process	GO:0006468	protein phosphorylation	AAK1	IDA		Human	PMID:18657069
Biological Process	GO:0006468	protein phosphorylation	Aak1	IDA		Rat	PMID:11877461|RGD:8553925
Biological Process	GO:0050821	protein stabilization	AAK1	IDA		Human	PMID:21464124
Biological Process	GO:2000369	regulation of clathrin-dependent endocytosis	AAK1	IMP		Human	PMID:17494869
Biological Process	GO:2000369	regulation of clathrin-dependent endocytosis	AAK1	IDA		Human	PMID:18657069
Biological Process	GO:2000369	regulation of clathrin-dependent endocytosis	Aak1	IDA		Rat	PMID:11877461|RGD:8553925
Biological Process	GO:0032880	regulation of protein localization	AAK1	IDA		Human	PMID:18657069

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern