Aak1 MGI Mouse Gene Detail - MGI:1098687

Aak1 Gene Detail

Symbol

Aak1
Name

AP2 associated kinase 1
Synonyms

5530400K14Rik, D6Ertd245e, MGC:40785, mKIAA1048

Feature Type

protein coding gene
IDs

MGI:1098687
NCBI Gene: 269774
Gene Overview

MyGene.info: AAK1

Sequence Map

Chr6:86849517-87003223 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

153707 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 37.75 cM
Mapping Data

4 experiments

Human Ortholog

AAK1, AP2 associated kinase 1

Vertebrate Orthologs

6

Human Ortholog

AAK1, AP2 associated kinase 1
Orthology source: HomoloGene, HGNC
Links

HGNC:19679

NCBI Gene ID: 22848

neXtProt AC: NX_Q2M2I8

UniProt: Q2M2I8
Chr Location

2p13.3; chr2:69457995-69643845 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 128746
1 human;1 mouse;1 rat;1 chimpanzee;1 dog;1 chicken
HCOP

human homology predictions: AAK1
Gene Tree

Aak1

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

20
Gene trapped

16
Spontaneous

1
Targeted

3
Genomic Mutations

1 involving Aak1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

41 strains or lines available

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All GO Annotations

21
GO References

3

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

46
Tissues

15
cDNA Data

20
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase aak1

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Aak1 interacts with 497 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

70
RefSeq

10
CCDS

CCDS20317.1, CCDS39544.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000024486	VEGA Gene Model \| MGI Sequence Detail	153707	C57BL/6J	± kb
transcript	OTTMUST00000060077	VEGA \| MGI Sequence Detail	19341	Not Applicable
polypeptide	OTTMUSP00000029283	VEGA \| MGI Sequence Detail	959	Not Applicable

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SNPs within 2kb

1087 from dbSNP Build 142

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Protein Ontology

PR:000003526 AP2-associated protein kinase 1

(term hierarchy)

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All nucleic 22

cDNA 21

Primer pair 1

Microarray probesets 16

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MGI:1925924, MGI:2141600, MGI:2141601, MGI:2141755, MGI:2141797, MGI:2679265

Summaries

All 40

Developmental Gene Expression 2

Gene Ontology 3

Phenotypes 11
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 06/13/2017 MGI 6.10