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Aak1 Gene Detail
Summary
  • Symbol
    Aak1
  • Name
    AP2 associated kinase 1
  • Synonyms
    5530400K14Rik, D6Ertd245e, MGC:40785, mKIAA1048
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098687
    NCBI Gene: 269774
  • Gene Overview
    MyGene.info: AAK1
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr6:86849517-87003223 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      153707 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 37.75 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    AAK1, AP2 associated kinase 1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    AAK1, AP2 associated kinase 1
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 22848
    neXtProt AC: NX_Q2M2I8
    UniProt: Q2M2I8

  • Chr Location
    2p13.3; chr2:69457995-69643845 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    21
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    46
  • Tissues
    15
  • cDNA Data
    20
  • Literature Summary
    2
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024486 VEGA Gene Model | MGI Sequence Detail 153707 C57BL/6J ±  kb
transcript OTTMUST00000060077 VEGA | MGI Sequence Detail 19341 Not Applicable  
polypeptide OTTMUSP00000029283 VEGA | MGI Sequence Detail 959 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1087 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 22
    cDNA 21
    Primer pair 1

    Microarray probesets 16
Other
Accession IDs
less
MGI:1925924, MGI:2141600, MGI:2141601, MGI:2141755, MGI:2141797, MGI:2679265
References
more
  • Summaries
    All 40
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 11
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/10/2017
MGI 6.10 		The Jackson Laboratory