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Gene Expression Data
Assay Details
Assay
Reference: J:253351 Hanley O, et al., Parallel Pbx-Dependent Pathways Govern the Coalescence and Fate of Motor Columns. Neuron. 2016 Sep 7;91(5):1005-1020
Assay type: Immunohistochemistry
MGI Accession ID: MGI:8206371
Gene symbol: Foxp1
Gene name: forkhead box P1
Antibody: Anti-Foxp1
Results
Specimen 1B brachial (Pbx1): embryonic day 11.5 (more )
Note: Double labeled: green - Foxp1; red - Pbx1 (assay MGI:8206352).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord brachial region lateral motor column neuron Present Regionally restricted 1B Pbx1 Foxp1 Pbx1 colocalizes with Foxp1+ lateral motor column neurons at brachial levels.
Specimen 1C brachial (Pbx3): embryonic day 11.5 (more )
Note: Double labeled: green - Foxp1; red - Pbx3 (assay MGI:8206356).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord brachial region lateral motor column neuron Present Regionally restricted 1C Pbx3 Foxp1 Pbx3 is restricted to rostral brachial Foxp1+ lateral motor column neurons.
Specimen 2A Control: embryonic day 12.5 (more )
Note: Control animals are from age-matched littermates that are Cre-negative and either Pbx3+/+ or Pbx3+/-.
Structure Cell Type Level Pattern Image Note
TS20: spinal cord brachial region lateral motor column neuron Present 2A Control Expression was detected in lateral motor column neurons.
Specimen 2A PbxMNdelta: embryonic day 12.5; Olig2tm1(cre)Tmj/Olig2+, Pbx1tm1Koss/Pbx1tm1Koss, Pbx3tm1Mlc/Pbx3tm1Mlc (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS20: spinal cord brachial region lateral motor column neuron Weak 2A PbxMNdelta A dramatic reduction of expression was observed in the lateral motor column neurons.
Specimen 2G Control: embryonic day 12.5 (more )
Note: Control animals are from age-matched littermates that are Cre-negative and either Pbx3+/+ or Pbx3+/-.
Structure Cell Type Level Pattern Image Note
TS20: spinal cord thoracic region spinal cord motor neuron Weak Regionally restricted 2G Control Expression was in preganglionic motor column neurons.
Specimen 2G PbxMNdelta: embryonic day 12.5; Olig2tm1(cre)Tmj/Olig2+, Pbx1tm1Koss/Pbx1tm1Koss, Pbx3tm1Mlc/Pbx3tm1Mlc (more )
Note: Conditional mutant.
Structure Cell Type Level Pattern Image Note
TS20: spinal cord thoracic region spinal cord motor neuron Absent 2G PbxMNdelta
Specimen 7A brachial (Mecom): embryonic day 12.5 (more )
Note: Double labeled: red - Foxp1; green - Mecom (assay MGI:8209108).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord brachial region lateral motor column neuron Present 7A Foxp1 Mecom Expression was not co-localized with Mecom.
Specimen 7B thoracic (Mecom): embryonic day 12.5 (more )
Note: Double labeled: red - Foxp1; green - Mecom (assay MGI:8209108).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord thoracic region spinal cord motor neuron Present Regionally restricted 7B Foxp1 Mecom Expression was detected in preganglionic motor column, but did not co-localize with Mecom.
Specimen S1A thoracic: embryonic day 11.5 (more )
Note: Double labeled: green - Foxp1; red - Pbx1 (assay MGI:8206352).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord thoracic region spinal cord motor neuron Present Regionally restricted S1A Pbx1 Foxp1 thoracic Expression was colocalized with Pbx1 in preganglionic motor column neurons.
Specimen S1C (Pbx3): embryonic day 11.5 (more )
Note: Double labeled: green - Foxp1; red - Pbx3 (assay MGI:8206356).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord brachial region lateral motor column neuron Present Regionally restricted S1C Pbx3 Foxp1 Expression was in lateral motor column neurons in the rostral brachial region and colocalized Pbx3.
Specimen S1C (Pbx1): embryonic day 11.5 (more )
Note: Double labeled: green - Foxp1; red - Pbx1 (assay MGI:8206352).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord brachial region lateral motor column neuron Present Regionally restricted S1C Pbx1 Foxp1 Expression was in lateral motor column neurons in the rostral brachial region and colocalized Pbx1.
Specimen S1D (Pbx3): embryonic day 11.5 (more )
Note: Double labeled: green - Foxp1; red - Pbx3 (assay MGI:8206356).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord brachial region lateral motor column neuron Present Regionally restricted S1D Pbx3 Foxp1 Expression was in lateral motor column neurons in the caudal brachial region and colocalized with Pbx3 in a subset of neurons.
Specimen S1D (Pbx1): embryonic day 11.5 (more )
Note: Double labeled: green - Foxp1; red - Pbx1 (assay MGI:8206352).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord brachial region lateral motor column neuron Present Regionally restricted S1D Pbx1 Foxp1 Expression was in lateral motor column neurons in the caudal brachial region and colocalized with Pbx1 in a subset of neurons.
Specimen S1G Control rostral: embryonic day 12.5 (more )
Note: Double labeled: green - Foxp1; red - Pbx3 (assay MGI:8206356).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord brachial region lateral motor column neuron Present S1G Control rostral
Specimen S1G Pbx1MNdelta rostral: embryonic day 12.5; Olig2tm1(cre)Tmj/Olig2+, Pbx1tm1Koss/Pbx1tm1Koss (more )
Note: Conditional mutant. Double labeled: green - Foxp1; red - Pbx3 (assay MGI:8206356).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord brachial region lateral motor column neuron Present S1G Pbx1MNdelta rostral
Specimen S1G Control middle: embryonic day 12.5 (more )
Note: Double labeled: green - Foxp1; red - Pbx3 (assay MGI:8206356).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord brachial region lateral motor column neuron Present S1G Control
Specimen S1G Pbx1MNdelta middle: embryonic day 12.5; Olig2tm1(cre)Tmj/Olig2+, Pbx1tm1Koss/Pbx1tm1Koss (more )
Note: Conditional mutant. Double labeled: green - Foxp1; red - Pbx3 (assay MGI:8206356).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord brachial region lateral motor column neuron Present S1G Pbx1MNdelta
Specimen S1G Control caudal: embryonic day 12.5 (more )
Note: Double labeled: green - Foxp1; red - Pbx3 (assay MGI:8206356).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord brachial region lateral motor column neuron Present S1G Control caudal
Specimen S1G Pbx1MNdelta caudal: embryonic day 12.5; Olig2tm1(cre)Tmj/Olig2+, Pbx1tm1Koss/Pbx1tm1Koss (more )
Note: Conditional mutant. Double labeled: green - Foxp1; red - Pbx3 (assay MGI:8206356).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord brachial region lateral motor column neuron Present S1G Pbx1MNdelta caudal
Specimen S2A Pbx3+/-: embryonic day 12.5; Pbx3tm1Mlc/Pbx3+ (more )
Structure Cell Type Level Pattern Image Note
TS20: spinal cord brachial region lateral motor column neuron Present S2A Foxp1 Pbx3+/-
Specimen S2A Pbx3-/-: embryonic day 12.5; Pbx3tm1Mlc/Pbx3tm1Mlc (more )
Structure Cell Type Level Pattern Image Note
TS20: spinal cord brachial region lateral motor column neuron Present S2A Foxp1 Pbx3-/- Lateral motor column differentiation is preserved in Pbx3-/- mice at E12.5.
Specimen S2C: embryonic day 12.5; Olig2tm1(cre)Tmj/Olig2+, Pbx1tm1Koss/Pbx1tm1Koss, Pbx3tm1Mlc/Pbx3+ (more )
Note: Conditional mutant. Double labeled: green - Foxp1; red - Isl1 (assay MGI:8206395) and Isl2 (assay MGI:8207778).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord thoracic region spinal cord motor neuron Weak Regionally restricted S2C Isl1/2 Foxp1 , S2C Foxp1 Expression was reduced in preganglionic motor column neurons in Pbx1MNdelta,Pbx3+/- mice.
Specimen S2D1 Control rostral: embryonic day 12.5 (more )
Note: Double labeled: red - Foxp1; green - Pbx1 (assay MGI:8206352).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord lateral motor column neuron Present S2D1 rostral Control
Specimen S2D1 Pbx1MNdelta rostral: embryonic day 12.5; Olig2tm1(cre)Tmj/Olig2+, Pbx1tm1Koss/Pbx1tm1Koss (more )
Note: Conditional mutant. Double labeled: red - Foxp1; green - Pbx1 (assay MGI:8206352).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord lateral motor column neuron Present S2D1 rostral Pbx1MNdelta In Pbx1MN1delta mutants there is a reduction in the size of the lateral motor column, as assessed by Foxp1 expression.
Specimen S2D2 Control: embryonic day 12.5 (more )
Note: Double labeled: red - Foxp1; green - Pbx1 (assay MGI:8206352).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord lateral motor column neuron Present S2D2 Control
Specimen S2D2 Pbx1MNdelta: embryonic day 12.5; Olig2tm1(cre)Tmj/Olig2+, Pbx1tm1Koss/Pbx1tm1Koss (more )
Note: Conditional mutant. Double labeled: red - Foxp1; green - Pbx1 (assay MGI:8206352).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord lateral motor column neuron Present S2D2 Pbx1MNdelta In Pbx1MN1delta mutants there is a reduction in the size of the lateral motor column, as assessed by Foxp1 expression.
Specimen S2D3 Control: embryonic day 12.5 (more )
Note: Double labeled: red - Foxp1; green - Pbx1 (assay MGI:8206352).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord lateral motor column neuron Present S2D3 Control
Specimen S2D3 Pbx1MNdelta: embryonic day 12.5; Olig2tm1(cre)Tmj/Olig2+, Pbx1tm1Koss/Pbx1tm1Koss (more )
Note: Conditional mutant. Double labeled: red - Foxp1; green - Pbx1 (assay MGI:8206352).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord lateral motor column neuron Present S2D3 Pbx1MNdelta In Pbx1MN1delta mutants there is a reduction in the size of the lateral motor column, as assessed by Foxp1 expression.
Specimen S2D4 Control: embryonic day 12.5 (more )
Note: Double labeled: red - Foxp1; green - Pbx1 (assay MGI:8206352).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord lateral motor column neuron Present S2D4 Control
Specimen S2D4 Pbx1MNdelta: embryonic day 12.5; Olig2tm1(cre)Tmj/Olig2+, Pbx1tm1Koss/Pbx1tm1Koss (more )
Note: Conditional mutant. Double labeled: red - Foxp1; green - Pbx1 (assay MGI:8206352).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord lateral motor column neuron Present S2D4 Pbx1MNdelta In Pbx1MN1delta mutants there is a reduction in the size of the lateral motor column, as assessed by Foxp1 expression.
Specimen S2D5 Control caudal: embryonic day 12.5 (more )
Note: Double labeled: red - Foxp1; green - Pbx1 (assay MGI:8206352).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord lateral motor column neuron Present S2D5 caudal Control
Specimen S2D5 Pbx1MNdelta caudal: embryonic day 12.5; Olig2tm1(cre)Tmj/Olig2+, Pbx1tm1Koss/Pbx1tm1Koss (more )
Note: Conditional mutant. Double labeled: red - Foxp1; green - Pbx1 (assay MGI:8206352).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord lateral motor column neuron Present S2D5 caudal Pbx1MNdelta In Pbx1MN1delta mutants there is a reduction in the size of the lateral motor column, as assessed by Foxp1 expression.
Specimen S2E Control rostral: embryonic day 12.5 (more )
Note: Double labeled: green - Foxp1; red - Aldh1a2 (assay MGI:8207781).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord lateral motor column neuron Present S2E rostral Control
Specimen S2E Pbx1MNdelta rostral: embryonic day 12.5; Olig2tm1(cre)Tmj/Olig2+, Pbx1tm1Koss/Pbx1tm1Koss (more )
Note: Conditional mutant. Double labeled: green - Foxp1; red - Aldh1a2 (assay MGI:8207781).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord lateral motor column neuron Present Regionally restricted S2E rostral Pbx1MNdelta There was a reduction in Foxp1+ Raldh2+ lateral motor column neurons in Pbx1MNdelta mutants.
Specimen S2E Control middle: embryonic day 12.5 (more )
Note: Double labeled: green - Foxp1; red - Aldh1a2 (assay MGI:8207781).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord lateral motor column neuron Present S2E Control
Specimen S2E Pbx1MNdelta middle: embryonic day 12.5; Olig2tm1(cre)Tmj/Olig2+, Pbx1tm1Koss/Pbx1tm1Koss (more )
Note: Conditional mutant. Double labeled: green - Foxp1; red - Aldh1a2 (assay MGI:8207781).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord lateral motor column neuron Present Regionally restricted S2E Pbx1MNdelta There was a reduction in Foxp1+ Raldh2+ lateral motor column neurons in Pbx1MNdelta mutants.
Specimen S2E Control caudal: embryonic day 12.5 (more )
Note: Double labeled: green - Foxp1; red - Aldh1a2 (assay MGI:8207781).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord lateral motor column neuron Present S2E caudal Control
Specimen S2E Pbx1MNdelta caudal: embryonic day 12.5; Olig2tm1(cre)Tmj/Olig2+, Pbx1tm1Koss/Pbx1tm1Koss (more )
Note: Conditional mutant. Double labeled: green - Foxp1; red - Aldh1a2 (assay MGI:8207781).
Structure Cell Type Level Pattern Image Note
TS20: spinal cord lateral motor column neuron Present Regionally restricted S2E caudal Pbx1MNdelta There was a reduction in Foxp1+ Raldh2+ lateral motor column neurons in Pbx1MNdelta mutants.
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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