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Gene Expression Data
Assay Details
Assay
Reference: J:302538 Ulmke PA, et al., Post-transcriptional regulation by the exosome complex is required for cell survival and forebrain development via repression of P53 signaling. Development. 2021 Feb 8;148(3):dev188276
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7490321
Gene symbol: Sox2
Gene name: SRY (sex determining region Y)-box 2
Antibody: anti-Sox2
Detection system: Secondary antibody
Assay notes: Two Sox2 antibodies were described, but the one used in this assay was not detailed. Anti-Sox2 MGI:7490283 may have been used in this assay.
Results
Specimen S2B Control: embryonic day 11.5 (more )
Note: Double labeled: green - Sox2; magenta - Rbfox3 (assay MGI:7490323).
Structure Level Pattern Image Note
TS19: diencephalon Present Regionally restricted S2B Control Expression in primordial neural stem cells.
TS19: midbrain Present Regionally restricted S2B Control Expression in primordial neural stem cells.
TS19: telencephalon Present Regionally restricted S2B Control Expression in dorsolateral part of telencephalon.
Specimen S2B cKO: embryonic day 11.5; Exosc10tm1.1Vlcg/Exosc10tm1.1Vlcg, Foxg1tm1(cre)Skm/Foxg1+ (more )
Note: Conditional mutant. Double labeled: green - Sox2; magenta - Rbfox3 (assay MGI:7490323).
Structure Level Pattern Image Note
TS19: diencephalon Present Regionally restricted S2B cKO Expression in primordial neural stem cells.
TS19: midbrain Present Regionally restricted S2B cKO Expression in primordial neural stem cells.
TS19: telencephalon Absent S2B cKO
Specimen 3B Rostral Control: embryonic day 13.5 (more )
Note: Double labeled: red - Sox2; green - Rbfox3 (assay MGI:7490323).
Structure Level Pattern Image Note
TS21: cerebral cortex ventricular layer Present Regionally restricted 3B Rostral Control Expression in apical progenitors.
Specimen 3B Rostral cKO: embryonic day 13.5; Emx1tm1(cre)Krj/Emx1+, Exosc10tm1.1Vlcg/Exosc10tm1.1Vlcg (more )
Note: Conditional mutant. Double labeled: red - Sox2; green - Rbfox3 (assay MGI:7490323).
Structure Level Pattern Image Note
TS21: cerebral cortex ventricular layer Present Regionally restricted 3B Rostral cKO Expression in apical progenitors comparable to control.
Specimen 3B Caudal Control: embryonic day 13.5 (more )
Note: Double labeled: red - Sox2; green - Rbfox3 (assay MGI:7490323).
Structure Level Pattern Image Note
TS21: cerebral cortex ventricular layer Present Regionally restricted 3B Caudal Control Expression in apical progenitors.
Specimen 3B Caudal cKO: embryonic day 13.5; Emx1tm1(cre)Krj/Emx1+, Exosc10tm1.1Vlcg/Exosc10tm1.1Vlcg (more )
Note: Conditional mutant. Double labeled: red - Sox2; green - Rbfox3 (assay MGI:7490323).
Structure Level Pattern Image Note
TS21: cerebral cortex ventricular layer Present Regionally restricted 3B Caudal cKO Expression in apical progenitors comparable to control.
Specimen 4A Control: embryonic day 13.5 (more )
Note: Double labeled: green - Sox2; red - Casp3 (assay MGI:7490334).
Structure Level Pattern Image Note
TS21: cerebral cortex Present Regionally restricted 4A Control , 4A Control inset Expression in apical progenitors.
Specimen 4A cKO: embryonic day 13.5; Emx1tm1(cre)Krj/Emx1+, Exosc10tm1.1Vlcg/Exosc10tm1.1Vlcg (more )
Note: Conditional mutant. Double labeled: green - Sox2; red - Casp3 (assay MGI:7490334).
Structure Level Pattern Image Note
TS21: cerebral cortex Present Regionally restricted 4A cKO inset , 4A cKO Co-expression with Casp3 in apical progenitors.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/28/2024
MGI 6.13 		The Jackson Laboratory