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Gene Expression Data
Assay Details
Assay
Reference: J:308695 Talley MJ, et al., Generation of a Mouse Model to Study the Noonan Syndrome Gene Lztr1 in the Telencephalon. Front Cell Dev Biol. 2021;9:673995
Assay type: Immunohistochemistry
MGI Accession ID: MGI:7281508
Gene symbol: Mapk1
Gene name: mitogen-activated protein kinase 1
Antibody: anti-Phospho-p44/42 MAP Kinase (Thr202/Tyr204) antibody (#9101)
Assay notes: The antibody recognized the phosphorylated form of the proteins Mapk1/Mapk3 (assay MGI:7281513). Two antibodies for the phosphorylated forms were described MGI:2677398 and MGI:5574505; either could have been used in this assay.
Results
Specimen 2C,E: postnatal day 21 (more )
Structure Level Pattern Image Note
TS28: corpus callosum Present 2C , 2E
TS28: cerebral cortex Present 2C
Specimen 2D,F: postnatal day 21; Lztr1tm1b(EUCOMM)Wtsi/Lztr1tm1c(EUCOMM)Wtsi, Foxg1tm1.1(cre)Ddmo/Foxg1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: corpus callosum Present 2F , 2D Enhanced immunoreactivity for phosphorylated Mapk1/Mapk3 was detected in the corpus callosum of the conditional mutant compared to control. This was observed at all levels of the corpus callosum, including the lateral, medial, and caudal regions. The increase in staining was observed in the white matter and in distinct cells bodies (~30.1% increase compared with control cell bodies).
TS28: cerebral cortex Present 2D Expression in the cerebral cortex was not enhanced in the conditional mutant.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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