Lztr1tm1b(EUCOMM)Wtsi
Targeted Allele Detail
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Symbol: |
Lztr1tm1b(EUCOMM)Wtsi |
Name: |
leucine-zipper-like transcriptional regulator, 1; targeted mutation 1b, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:7281479 |
Synonyms: |
Lztr1lacZ |
Gene: |
Lztr1 Location: Chr16:17326552-17344197 bp, + strand Genetic Position: Chr16, 10.85 cM
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Alliance: |
Lztr1tm1b(EUCOMM)Wtsi page
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IMPC: |
Lztr1 gene page |
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Mutant Cell Line: |
EPD0140_5_E07 |
Germline Transmission: |
Earliest citation of germline transmission:
J:308695
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Parent Cell Line: |
JM8.N4 (ES Cell)
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Strain of Origin: |
C57BL/6N
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Project Collection: |
EUCOMM
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
Vector: L1L2_Bact_P
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Mutation details: The L1L2_Bact_P cassette was inserted at position 17335891 of Chromosome 16 upstream of the critical exon 7 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon 7 at position 17336675. The critical exon 7 is thus flanked by loxP sites. Cre-mediated recombination removed the neomycin resistance gene and exon 7, generating a reporter knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml.
(J:308695)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Lztr1 Mutation: |
37 strains or lines available
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Original: |
J:308695 Talley MJ, et al., Generation of a Mouse Model to Study the Noonan Syndrome Gene Lztr1 in the Telencephalon. Front Cell Dev Biol. 2021;9:673995 |
All: |
1 reference(s) |
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