Lztr1^{tm1c(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Lztr1^{tm1c(EUCOMM)Wtsi}
• Name: leucine-zipper-like transcriptional regulator, 1; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:7281483
• Synonyms: Lztr1^fx
• Gene: Lztr1 Location: Chr16:17326552-17344197 bp, + strand Genetic Position: Chr16, 10.85 cM
• Alliance: Lztr1^{tm1c(EUCOMM)Wtsi} page
• IMPC: Lztr1 gene page

Mutation origin

• Mutant Cell Line: EPD0140_5_E07
• Germline Transmission: Earliest citation of germline transmission: J:308695
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion Vector: L1L2_Bact_P
• Mutation details: The L1L2_Bact_P cassette was inserted at position 17335891 of Chromosome 16 upstream of the critical exon 7 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon 7 at position 17336675. The critical exon 7 is thus flanked by loxP sites. Flp-mediated recombination removed the lacZ and neomycin resistance gene, generating a "conditional ready" exon 7 floxed allele. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:308695)

Expression

In Mice Carrying this Mutation:

42 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lztr1 Mutation: 42 strains or lines available

References

• Original: J:308695 Talley MJ, et al., Generation of a Mouse Model to Study the Noonan Syndrome Gene Lztr1 in the Telencephalon. Front Cell Dev Biol. 2021;9:673995
• All: 4 reference(s)