About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:149463 Lania G, et al., Early thyroid development requires a Tbx1-Fgf8 pathway. Dev Biol. 2009 Apr 1;328(1):109-17
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6423602
Gene symbol: Nkx2-1
Gene name: NK2 homeobox 1
Antibody: anti-Titf1/Nkx2.1
Detection system: Biotinylated secondary antibody/[Strept]avidin
Results
Specimen 1b: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: thyroid gland follicle Present 1b
Specimen 1b': embryonic day 18.5; Tbx1tm1Bld/Tbx1tm1Bld (more )
Structure Level Pattern Image Note
TS26: thyroid gland follicle Present 1b' Normal expression. Lumen of thyroid follicles appeared slight enlarged.
Specimen 2a: embryonic day 9.0 (more )
Structure Level Pattern Image Note
TS14: thyroid primordium Present 2a Expression in clearly identifiable primordium - well-organized bi-layer in ventral endoderm of primitive pharynx.
Specimen 2a': embryonic day 9.0; Tbx1tm1Bld/Tbx1tm1Bld (more )
Structure Level Pattern Image Note
TS14: thyroid primordium Present Clusters 2a' Expression in clustered cells, not organized in characteristic bi-layer morphology as seen in controls.
Specimen 2b: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: thyroid primordium endoderm Present Regionally restricted 2b Precursor cells invaded surrounding mesenchyme to form primordium.
Specimen 2b': embryonic day 9.5; Tbx1tm1Bld/Tbx1tm1Bld (more )
Structure Level Pattern Image Note
TS15: thyroid primordium Present 2b'
Specimen 2c: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: thyroid primordium Present 2c
Specimen 2c': embryonic day 10.5; Tbx1tm1Bld/Tbx1tm1Bld (more )
Structure Level Pattern Image Note
TS17: thyroid primordium endoderm Present Regionally restricted 2c' Primordium is smaller than controls. Delayed migration toward aortic sac, with a persistent thyroglossal duct constituting continuity between primordium and pharyngeal endoderm.
Specimen 3b: embryonic day 9.5; Mesp1tm2(cre)Ysa/Mesp1+, Tbx1tm3.1Bld/Tbx1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: thyroid primordium Present 3b
Specimen 3b': embryonic day 9.5; Mesp1tm2(cre)Ysa/Mesp1+, Tbx1tm3Bld/Tbx1tm3.1Bld (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: thyroid primordium Present 3b' Differentiated primordium is smaller and flatter than in controls.
Specimen 4c: embryonic day 9.5; Fgf8tm1.3Mrt/Fgf8+, Tbx1tm6(cre)Bld/Tbx1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: thyroid primordium Present 4c
Specimen 4c': embryonic day 9.5; Fgf8tm1Mrc/Fgf8tm1.3Mrt, Tbx1tm6(cre)Bld/Tbx1+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS15: thyroid primordium Present 4c' Primordium is differentiated but smaller than controls.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/21/2024
MGI 6.23 		The Jackson Laboratory