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Gene Expression Data
Assay Details
Assay
Reference: J:132598 Nishimura W, et al., Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice. Dev Biol. 2008 Feb 15;314(2):443-56
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6382862
Gene symbol: Mafb
Gene name: MAF bZIP transcription factor B
Antibody: anti-MafB (BL658)
Detection system: Biotinylated secondary antibody/[Strept]avidin coupled to Alexa Fluor 488
Results
Specimen 1B: embryonic day 15.5 (more )
Note: Double labeled: green - Mafb; red - Ins1 (assay MGI:6382865) and Ins2 (assay MGI:6382879).
Structure Level Pattern Image Note
TS23: pancreas Present 1B
Specimen 1F: embryonic day 15.5; Pax6Sey-Neu/Pax6+ (more )
Note: Double labeled: green - Mafb; red - Ins1 (assay MGI:6382865) and Ins2 (assay MGI:6382879).
Structure Level Pattern Image Note
TS23: pancreas Weak 1F Number of expressing cells significantly reduced compared with wild type.
Specimen 1J: embryonic day 17.5 (more )
Note: Double labeled: green - Mafb; red - Ins1 (assay MGI:6382865) and Ins2 (assay MGI:6382879).
Structure Level Pattern Image Note
TS25: pancreas Present 1J
Specimen 1N: embryonic day 17.5; Pax6Sey-Neu/Pax6+ (more )
Note: Double labeled: green - Mafb; red - Ins1 (assay MGI:6382865) and Ins2 (assay MGI:6382879).
Structure Level Pattern Image Note
TS25: pancreas Trace Regionally restricted 1N Greater reduction in number of expressing cells at E17.5 than at E15.5. Majority of expression restricted to insulin-expressing cells.
Specimen 3C: embryonic day 12.5 (more )
Note: Double labeled: green - Mafb; red - Gluc (Gcg assay MGI:6382866).
Structure Level Pattern Image Note
TS20: pancreas Present 3C
Specimen 3G: embryonic day 12.5; Pax6Sey-Neu/Pax6+ (more )
Note: Double labeled: green - Mafb; red - Gluc (Gcg assay MGI:6382866).
Structure Level Pattern Image Note
TS20: pancreas Weak 3G Expression reduced compared with wild type.
Specimen 3D: embryonic day 15.5 (more )
Note: Double labeled: green - Mafb; red - Gluc (Gcg assay MGI:6382866).
Structure Level Pattern Image Note
TS23: pancreas Present 3D
Specimen 3H: embryonic day 15.5; Pax6Sey-Neu/Pax6+ (more )
Note: Double labeled: green - Mafb; red - Gluc (Gcg assay MGI:6382866).
Structure Level Pattern Image Note
TS23: pancreas Weak 3H Expression reduced compared with wild type.
Specimen S2C/D: embryonic day 15.5 (more )
Note: Double labeled: green - Mafb; red - Ghrelin (Ghrl assay MGI:6382873).
Structure Level Pattern Image Note
TS23: pancreas Present S2C , S2D
Specimen S2E/F: embryonic day 15.5; Pax6Sey-Neu/Pax6+ (more )
Note: Double labeled: green - Mafb; red - Ghrelin (Ghrl assay MGI:6382873).
Structure Level Pattern Image Note
TS23: pancreas Weak S2E , S2F Expression reduced compared with wild type.
Specimen 7A: embryonic day 15.5 (more )
Note: Double labeled: green - Mafb; red - Ins1 (assay MGI:6382863) and Ins2 (assay MGI:6382879).
Structure Level Pattern Image Note
TS23: pancreas Present 7A
Specimen 7E: embryonic day 15.5; Mafbm1Gsb/Mafbm1Gsb (more )
Note: Double labeled: green - Mafb; red - Ins1 (assay MGI:6382863) and Ins2 (assay MGI:6382879).
Structure Level Pattern Image Note
TS23: pancreas Present 7E Modest increase in number of expressing cells compared with wild type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory