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Gene Expression Data
Assay Details
Assay
Reference: J:57262 Song J, et al., The type II activin receptors are essential for egg cylinder growth, gastrulation, and rostral head development in mice. Dev Biol. 1999 Sep 1;213(1):157-69
Assay type: RNA in situ
MGI Accession ID: MGI:5491488
Gene symbol: Otx2
Gene name: orthodenticle homeobox 2
Probe: pOtd9
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Assay notes: Expression was detected using NBT/BCIP for the color reaction.
Results
Specimen 4D: embryonic day 8.5 (more )
Structure Level Pattern Image Note
TS13: neural ectoderm Present Regionally restricted 4D Expression in anterior third of neural plate.
Specimen 4E: embryonic day 9.5 (more )
Note: Double labeled: purple - Otx2; orange - En2 (assay MGI:5491489).
Structure Level Pattern Image Note
TS15: future forebrain Present 4E
TS15: future midbrain Present 4E
Specimen 4I: embryonic day 8.5; Acvr2atm1Hsch/Acvr2atm1Hsch, Acvr2btm1Enl/Acvr2b+ (more )
Structure Level Pattern Image Note
TS13: embryo Present Regionally restricted 4I Expression at anterior tip of embryo.
TS13: future prosencephalon Present Regionally restricted 4I Abnormal expression in the forebrain region.
Specimen 4J: embryonic day 9.5; Acvr2atm1Hsch/Acvr2atm1Hsch, Acvr2btm1Enl/Acvr2b+ (more )
Note: Double labeled: purple - Otx2; orange - En2 (assay MGI:5491489).
Structure Level Pattern Image Note
TS15: future brain Present Regionally restricted 4J Expression domain is truncated.
Specimen 4K: embryonic day 9.5; Acvr2atm1Hsch/Acvr2atm1Hsch, Acvr2btm1Enl/Acvr2b+ (more )
Note: Double labeled: purple - Otx2; orange - En2 (assay MGI:5491489).
Structure Level Pattern Image Note
TS15: future brain Present Regionally restricted 4K Expression domain is reduced. Anterior part of expression domain is truncated.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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