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Gene Expression Data
Assay Details
Assay
Reference: J:139974 Sakae N, et al., Mice lacking the schizophrenia-associated protein FEZ1 manifest hyperactivity and enhanced responsiveness to psychostimulants. Hum Mol Genet. 2008 Oct 15;17(20):3191-203
Assay type: Immunohistochemistry
MGI Accession ID: MGI:3812194
Gene symbol: Fez1
Gene name: fasciculation and elongation protein zeta 1
Antibody: anti-Fez1
Detection system: Secondary antibody coupled to rhodamine
Results
Specimen 1C WT: postnatal week 12-15 (more )
Note: Double labeled: red - Fez1; green - Gad1 (assay MGI:3812211).
Structure Level Pattern Image Note
TS28: dentate gyrus granule cell layer Present Regionally restricted 1C FEZ1 WT , 1C WT merge Expression is present in axon bundles that form the mossy fiber pathway.
TS28: hippocampus CA3 Present Regionally restricted 1D WT , 1C FEZ1 WT , 1C WT merge Expression is present in axon bundles that form the mossy fiber pathway.
Specimen 1C KO: postnatal week 12-15; Fez1tm1Kei/Fez1tm1Kei (more )
Note: Double labeled: red - Fez1; green - Gad1 (assay MGI:3812211).
Structure Level Pattern Image Note
TS28: dentate gyrus granule cell layer Absent 1C FEZ1 KO , 1C KO merge
TS28: hippocampus CA3 Absent 1C FEZ1 KO , 1C KO merge , 1D KO
Specimen 1E WT: postnatal week 12-15 (more )
Note: Double labeled: red - Fez1; green - Gad1 (assay MGI:3812211).
Structure Level Pattern Image Note
TS28: hippocampus CA1 Present Regionally restricted 1E WT merge , 1E FEZ1 WT Expression is present in GABA-ergic inhibitory neurons.
Specimen 1E KO: postnatal week 12-15; Fez1tm1Kei/Fez1tm1Kei (more )
Note: Double labeled: red - Fez1; green - Gad1 (assay MGI:3812211).
Structure Level Pattern Image Note
TS28: hippocampus CA1 Absent 1E KO merge , 1E FEZ1 KO
Specimen 1F WT: postnatal week 12-15 (more )
Note: Double labeled: red - Fez1; green - Gad1 (assay MGI:3812211).
Structure Level Pattern Image Note
TS28: cortical layer II Present Regionally restricted 1F FEZ1 WT , 1F WT merge Expression is present in GABA-ergic inhibitory neurons.
TS28: cortical layer III Present Regionally restricted 1F FEZ1 WT , 1F WT merge Expression is present in GABA-ergic inhibitory neurons.
Specimen 1F KO: postnatal week 12-15; Fez1tm1Kei/Fez1tm1Kei (more )
Note: Double labeled: red - Fez1; green - Gad1 (assay MGI:3812211).
Structure Level Pattern Image Note
TS28: cortical layer II Absent 1F KO merge , 1F FEZ1 KO
TS28: cortical layer III Absent 1F KO merge , 1F FEZ1 KO
Specimen 1G WT: postnatal week 12-15 (more )
Note: Double labeled: red - Fez1; green - Gad1 (assay MGI:3812211).
Structure Level Pattern Image Note
TS28: caudate-putamen Present Regionally restricted 1G WT merge , 1G FEZ1 WT Expression is present in GABA-ergic inhibitory neurons.
Specimen 1G KO: postnatal week 12-15; Fez1tm1Kei/Fez1tm1Kei (more )
Note: Double labeled: red - Fez1; green - Gad1 (assay MGI:3812211).
Structure Level Pattern Image Note
TS28: caudate-putamen Absent 1G FEZ1 KO , 1G KO merge
Specimen 1H WT: postnatal week 12-15 (more )
Note: Double labeled: red - Fez1; green - Gad1 (assay MGI:3812211).
Structure Level Pattern Image Note
TS28: accumbens nucleus Present Regionally restricted 1H FEZ1 WT , 1H WT merge Expression is present in GABA-ergic inhibitory neurons.
Specimen 1H KO: postnatal week 12-15; Fez1tm1Kei/Fez1tm1Kei (more )
Note: Double labeled: red - Fez1; green - Gad1 (assay MGI:3812211).
Structure Level Pattern Image Note
TS28: accumbens nucleus Absent 1H FEZ1 KO , 1H KO merge
Specimen 1I WT upper: postnatal week 12-15 (more )
Note: Double labeled: red - Fez1; blue - Th (assay MGI:3812199).
Structure Level Pattern Image Note
TS28: substantia nigra pars compacta Absent 1I FEZ1 WT (upper) , 1I WT merge (upper) There is no expression in the somata of dopaminergic neurons.
Specimen 1I WT lower: postnatal week 12-15 (more )
Note: Double labeled: red - Fez1; blue - Th (assay MGI:3812199).
Structure Level Pattern Image Note
TS28: accumbens nucleus Present Regionally restricted 1I WT merge (lower) , 1I FEZ1 WT (lower) There is no expression in dopaminergic axon fibers projecting to the nucleus accumbens (although there is expression in GABA-ergic inhibitory neurons).
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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