Fez1 Gene Detail

Summary

• Symbol
  Fez1
• Name
  fasciculation and elongation protein zeta 1
• Synonyms
  MGC:19293, UNC76, UNC-76, zygin I

• Feature Type
  protein coding gene
• IDs
  MGI:2670976
  NCBI Gene: 235180
• Alliance
  gene page
• Transcription Start Sites
  2 TSS

Location &
Maps

• Sequence Map
  Chr9:36733160-36790220 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 9, 20.69 cM
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  333 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2670976	protein coding gene	Chr9:36732694-36790222 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034557	protein coding gene	Chr9:34741278-34806032 (+)
A/J	MGP_AJ_G0034536	protein coding gene	Chr9:33845037-33904676 (+)
AKR/J	MGP_AKRJ_G0034463	protein coding gene	Chr9:34591418-34651799 (+)
BALB/cJ	MGP_BALBcJ_G0034527	protein coding gene	Chr9:33684070-33743627 (+)
C3H/HeJ	MGP_C3HHeJ_G0034240	protein coding gene	Chr9:35019143-35081440 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035049	protein coding gene	Chr9:35875733-35940518 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031975	protein coding gene	Chr9:32973953-33030990 (+)
CAST/EiJ	MGP_CASTEiJ_G0033561	protein coding gene	Chr9:34699963-34826071 (+)
CBA/J	MGP_CBAJ_G0034213	protein coding gene	Chr9:37114751-37183403 (+)
DBA/2J	MGP_DBA2J_G0034371	protein coding gene	Chr9:33894147-33953928 (+)
FVB/NJ	MGP_FVBNJ_G0034312	protein coding gene	Chr9:33152366-33209792 (+)
LP/J	MGP_LPJ_G0034456	protein coding gene	Chr9:34982038-35042899 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034358	protein coding gene	Chr9:38761666-38822216 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035068	protein coding gene	Chr9:34523476-34585762 (+)
PWK/PhJ	MGP_PWKPhJ_G0033267	protein coding gene	Chr9:33801720-33861773 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033101	protein coding gene	Chr9:34730853-34849213 (+)
WSB/EiJ	MGP_WSBEiJ_G0033677	protein coding gene	Chr9:34326804-34389011 (+)

Homology

• Human Ortholog
  FEZ1, fasciculation and elongation protein zeta 1

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  FEZ1, fasciculation and elongation protein zeta 1
  
• Synonyms
  UNC-76
• Links
  HGNC:3659

  NCBI Gene ID: 9638

  neXtProt AC: NX_Q99689

  UniProt: Q99689

  
  
• Chr Location
  11q24.2; chr11:125442881-125592568 (-)  GRCh38

---

• MGI Vertebrate Homology
  Fez1 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: FEZ1
• Gene Tree
  Fez1
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  10 phenotypes from 1 allele in 2 genetic backgrounds
  7 phenotype references
  

• All Mutations and Alleles
  44
• Endonuclease-mediated
  1
• Gene trapped
  41
• Targeted
  2
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  34 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Mice homozygous for a null allele exhibit hyperactivity and increased sensitivity to methamphetamine.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  24
• GO References
  7

Expression

• Assay Results
  788
• Tissues
  47
• cDNA Data
  53
• Literature Summary
  5

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase fez1
  ZFIN fez1

Sequences &
Gene Models

• All Sequences
  73
• RefSeq
  18
• UniProt
  8
• CCDS
  CCDS40581.1

• Ensembl
  ENSMUSG00000032118 (Evidence)
• NCBI Gene
  235180

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000032118	Ensembl Gene Model | MGI Sequence Detail	57061	C57BL/6J
transcript	ENSMUST00000034630	Ensembl | MGI Sequence Detail	1794	Not Applicable
polypeptide	ENSMUSP00000034630	Ensembl | MGI Sequence Detail	392	Not Applicable

Protein
Information

• UniProt
  8 Sequences
• Protein Ontology
  PR:000007466 fasciculation and elongation protein zeta-1
  (term hierarchy)
• InterPro Domains
  IPR011680 Fasciculation and elongation protein zeta, FEZ

Molecular
Reagents

• All nucleic 56

  cDNA 54

  Primer pair 1

  Other 1

  
  

  Microarray probesets 2

References

• Summaries
  All 39

  Developmental Gene Expression 5

  Gene Ontology 7

  Phenotypes 7
• Earliest
  J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
• Latest
  J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Fez1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr84372	Chr9:36743996-36744151 (+)	10,914 bp
Tssr84373	Chr9:36761673-36761688 (+)	28,521 bp