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Phenotypes Associated with This Genotype
Genotype
MGI:5438822
cn19
Allelic
Composition
Rag1tm1.1Sadu/Rag1tm1.1Sadu
Trdctm1Mal/Trdctm1Mal
Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic
Background
involves: 129P2/OlaHsd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(cre/ERT2)Brn mutation (1 available); any Gt(ROSA)26Sor mutation (1096 available)
Rag1tm1.1Sadu mutation (0 available); any Rag1 mutation (133 available)
Trdctm1Mal mutation (1 available); any Trdc mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in un-induced mice
• however, tamoxifen induction rescues thymus size
• Vgamma4+ gamma delta T cells in the peripheral lymph nodes, spleen, lung and liver despite tamoxifen treatment of adult mice
• absent IL17+ cells despite tamoxifen treatment of adult mice
• Vgamma1+ gamma delta T cells in the spleen, lung and liver despite tamoxifen treatment of adult mice

hematopoietic system
• in un-induced mice
• however, tamoxifen induction rescues thymus size
• Vgamma4+ gamma delta T cells in the peripheral lymph nodes, spleen, lung and liver despite tamoxifen treatment of adult mice
• absent IL17+ cells despite tamoxifen treatment of adult mice
• Vgamma1+ gamma delta T cells in the spleen, lung and liver despite tamoxifen treatment of adult mice

endocrine/exocrine glands
• in un-induced mice
• however, tamoxifen induction rescues thymus size


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/24/2026
MGI 6.24
The Jackson Laboratory