Phenotypes Associated with This Genotype

Genotype
MGI:4941336

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Trp53^tm2Tyj/Trp53⁺; Tg(Pdx1-cre)6Tuv/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:98936 )

neoplasm

increased pancreatic ductal adenocarcinoma incidence ( J:98936 )

• all but one mouse, develop large, firm, fibrotic head of the pancreas tumors

• metastatic foci spread to the surface of the liver, lungs, diaphragm, and adrenals with occasional metastasis to the peripancreatic, mesenteric, and retroperitoneal lymph nodes

• mice exhibit the full spectrum of preinvasive lesions

• some tumors are minor, poorly differentiated, or undifferentiated with anaplastic or sarcomatoid features

increased pancreatic intraepithelial neoplasia incidence ( J:98936 )

• in young mice

increased T cell derived lymphoma incidence ( J:98936 )

• in 2 mice

increased teratocarcinoma incidence ( J:98936 )

• in one mouse

increased papilloma incidence ( J:98936 )

• some mice exhibit esophageal papillomas and hyperplasias or papillomatosis of the biliary tree unlike control mice

increased esophageal papilloma incidence ( J:98936 )

• in some mice

liver/biliary system

cholestasis ( J:98936 )

homeostasis/metabolism

hemorrhagic ascites ( J:98936 )

• hemorrhagic

cellular

chromosomal instability ( J:98936 )

• in tumor cells

growth/size/body

cachexia ( J:98936 )

distended abdomen ( J:98936 )

digestive/alimentary system

increased esophageal papilloma incidence ( J:98936 )

• in some mice

intestinal obstruction ( J:98936 )

• mice frequently exhibit small bowel obstructions unlike control mice

endocrine/exocrine glands

increased pancreatic ductal adenocarcinoma incidence ( J:98936 )

• all but one mouse, develop large, firm, fibrotic head of the pancreas tumors

• metastatic foci spread to the surface of the liver, lungs, diaphragm, and adrenals with occasional metastasis to the peripancreatic, mesenteric, and retroperitoneal lymph nodes

• mice exhibit the full spectrum of preinvasive lesions

• some tumors are minor, poorly differentiated, or undifferentiated with anaplastic or sarcomatoid features

increased pancreatic intraepithelial neoplasia incidence ( J:98936 )

• in young mice

increased T cell derived lymphoma incidence ( J:98936 )

• in 2 mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatic ductal adenocarcinoma		DOID:3498		J:98936