Analysis Tools
reproductive system
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• spermatocytes and oocytes show a deficiency in crossover licensing
• mice show a reduction of the localization of pro-crossover factors (MSH4, TEX11, RPA, MZIP2) and absence of late crossover-intermediates (MLH1) and this loss of most crossovers by diakinesis results in mostly univalent chromosomes
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• pachytene oocytes from females lack MLH1 foci and metaphase I chromosomes have no chiasmata
• most of the metaphase I/diakinesis spermatocytes display univalent chromosomes with only a fraction forming chiasmata
• loss of most crossovers ultimately leads to loss of most chiasmata
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• mice exhibit synapsis defects between the sex chromosomes
• 25.7% of oocytes show synapsis defects; oocyte chromosome spreads show non-homologous synapsis involving several autosomes
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• oocytes show a deficiency in crossover licensing
• however, ovaries are normal is size and show follicles at different states of folliculogenesis and several corpora lutea and ovaries at 4, 10, and 63-70 dpp show a slight, but not significant, reduction in the number of primordial follicles
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• spermatocytes show a deficiency in crossover licensing
• 32.2% of pachynemas show XY defects and extended gammaH2AX (phosphorylated form of histone H2AX) signal beyond the Sex Body into the autosomal domain
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• pachytene spermatocytes exhibit structural abnormalities involving the X and Y chromosomes, including ring chromosomes, fusions between X and an autosome, and autosynapsis of the X chromosome
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• spermatocyte accumulation is seen in tubules at stage XII of the seminiferous epithelial cycle with massive apoptosis of spermatocytes that fail to carry out the first meiotic division, and absence of spermatocytes progressing beyond this stage, suggesting a metaphase I arrest
• however, males show no differences in DNA double-strand break (DSB) induction in leptonema or zygonema, indicating normal progression of early DSB processing events
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• pachytene spermatocytes (corresponding to stage IV of the seminiferous epithelial cycle) are seen entering into apoptosis
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• testes weight is reduced by 70%
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infertility
(
J:351318
)
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• males and females are sterile
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endocrine/exocrine glands
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• testes weight is reduced by 70%
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cellular
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• spermatocytes and oocytes show a deficiency in crossover licensing
• mice show a reduction of the localization of pro-crossover factors (MSH4, TEX11, RPA, MZIP2) and absence of late crossover-intermediates (MLH1) and this loss of most crossovers by diakinesis results in mostly univalent chromosomes
|
|
• pachytene oocytes from females lack MLH1 foci and metaphase I chromosomes have no chiasmata
• most of the metaphase I/diakinesis spermatocytes display univalent chromosomes with only a fraction forming chiasmata
• loss of most crossovers ultimately leads to loss of most chiasmata
|
|
• mice exhibit synapsis defects between the sex chromosomes
• 25.7% of oocytes show synapsis defects; oocyte chromosome spreads show non-homologous synapsis involving several autosomes
|
|
|
• oocytes show a deficiency in crossover licensing
• however, ovaries are normal is size and show follicles at different states of folliculogenesis and several corpora lutea and ovaries at 4, 10, and 63-70 dpp show a slight, but not significant, reduction in the number of primordial follicles
|
|
|
• spermatocytes show a deficiency in crossover licensing
• 32.2% of pachynemas show XY defects and extended gammaH2AX (phosphorylated form of histone H2AX) signal beyond the Sex Body into the autosomal domain
|
|
|
• pachytene spermatocytes exhibit structural abnormalities involving the X and Y chromosomes, including ring chromosomes, fusions between X and an autosome, and autosynapsis of the X chromosome
|
|
|
• spermatocyte accumulation is seen in tubules at stage XII of the seminiferous epithelial cycle with massive apoptosis of spermatocytes that fail to carry out the first meiotic division, and absence of spermatocytes progressing beyond this stage, suggesting a metaphase I arrest
• however, males show no differences in DNA double-strand break (DSB) induction in leptonema or zygonema, indicating normal progression of early DSB processing events
|
|
|
• pachytene spermatocytes (corresponding to stage IV of the seminiferous epithelial cycle) are seen entering into apoptosis
|
