Rnf212b^em1Amp
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rnf212b^em1Amp
• Name: ring finger protein 212B; endonuclease-mediated mutation 1, Alberto M Pendas
• MGI ID: MGI:8473469
• Gene: Rnf212b Location: Chr14:55051598-55091565 bp, + strand Genetic Position: Chr14, Syntenic
• Alliance: Rnf212b^em1Amp page

Mutation origin

• Strain of Origin: (C57BL/6J x CBA/J)F2

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details:

  CRISPR/Cas9-mediated recombination generated a 343 bp deletion that encompasses exon 2 which contains a Zn-RING domain. Western blot analysis confirmed absence of protein in testis extracts. (J:351318)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rnf212b Mutation: 3 strains or lines available

References

• Original: J:351318 Condezo YB, et al., RNF212B E3 ligase is essential for crossover designation and maturation during male and female meiosis in the mouse. Proc Natl Acad Sci U S A. 2024 Jun 18;121(25):e2320995121
• All: 1 reference(s)