Phenotypes associated with this allele

• Allele Symbol: Sbspon^em1Gpt
• Allele Name: endonuclease-mediated mutation 1, GemPharmatech
• Allele ID: MGI:8332027
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sbspon^em1Gpt/Sbspon^em1Gpt	involves: C57BL/6JGpt	MGI:8332030

Genotype
MGI:8332030

hm1

• Allelic Composition: Sbspon^em1Gpt/Sbspon^em1Gpt
• Genetic Background: involves: C57BL/6JGpt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:370648 )

• in BBN treated mice median survival time is 217 days and maximum survival time is 237 days, while only 1 wild-type mouse died at 177 days

neoplasm

increased incidence of tumors by chemical induction ( J:370648 )

• increased volume and total tumor burden in an N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN, 0.05% in water for 18 weeks) model of induced bladder cancer

• in BBN induced bladder tumors, tumor cells are more condensed and have larger nuclei

homeostasis/metabolism

decreased circulating bilirubin level ( J:370648 )

♂ • in males but not females

increased circulating alanine transaminase level ( J:370648 )

♂ • in males but not females

increased susceptibility to xenobiotic induced morbidity/mortality ( J:370648 )

• in BBN treated mice median survival time is 217 days and maximum survival time is 237 days, while only 1 wild-type mouse died at 177 days

increased incidence of tumors by chemical induction ( J:370648 )

• increased volume and total tumor burden in an N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN, 0.05% in water for 18 weeks) model of induced bladder cancer

• in BBN induced bladder tumors, tumor cells are more condensed and have larger nuclei

behavior/neurological

increased grip strength ( J:370648 )

♂ • in males but not females