Sbspon^em1Gpt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sbspon^em1Gpt
• Name: somatomedin B and thrombospondin, type 1 domain containing; endonuclease-mediated mutation 1, GemPharmatech
• MGI ID: MGI:8332027
• Synonyms: Sbspon^em1Cd
• Gene: Sbspon Location: Chr1:15924086-15962946 bp, - strand Genetic Position: Chr1, 4.89 cM
• Alliance: Sbspon^em1Gpt page
• IMPC: Sbspon gene page

Mutation origin

• Strain of Origin: C57BL/6JGpt
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/cas9-mediated recombination using two guide RNAs created a 113 bp deletion in exon 2. (J:370648)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sbspon Mutation: 22 strains or lines available

References

• Original: J:370648 Ni B, et al., Novel glycoprotein SBSPON suppressed bladder cancer through the AKT signal pathway by inhibiting HSPA5 membrane translocation. Int J Biol Sci. 2025;21(10):4586-4603
• All: 1 reference(s)