Phenotypes associated with this allele

• Allele Symbol: Pfkfb2^tm1Ntang
• Allele Name: targeted mutation 1, Nan Tang
• Allele ID: MGI:8328376
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor^tm4(ACTB-tdTomato,-EGFP)Luo Pfkfb2^tm1Ntang/Pfkfb2^tm1Ntang Sftpc^tm1(cre/ERT2)Blh/Sftpc^+	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6	MGI:8329626

Genotype
MGI:8329626

cn1

• Allelic Composition: Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}; Pfkfb2^tm1Ntang/Pfkfb2^tm1Ntang; Sftpc^{tm1(cre/ERT2)Blh}/Sftpc⁺
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased cellular ATP level ( J:353628 )

• reduced glycolytic ATP production in AT2 cells

homeostasis/metabolism

decreased cellular ATP level ( J:353628 )

• reduced glycolytic ATP production in AT2 cells

respiratory system

abnormal pulmonary alveolus epithelial cell morphology ( J:353628 )

• reduced number of AT1 cells 63 days after bleomycin-induced lung injury at age 12 months

• normal number of AT2 cells 63 days after bleomycin-induced lung injury at age 12 months

decreased type I pneumocyte number ( J:353628 )

• 63 days after bleomycin-induced lung injury at age 12 months

pulmonary fibrosis ( J:353628 )

• 63 days after bleomycin-induced lung injury at age 12 months

abnormal vital capacity ( J:353628 )

• reduced forced vital capacity 63 days after bleomycin-induced lung injury at age 12 months

decreased lung compliance ( J:353628 )

• 63 days after bleomycin-induced lung injury at age 12 months