Phenotypes associated with this allele

• Allele Symbol: Tmem25^tm1.1Hrwa
• Allele Name: targeted mutation 1.1, Hong-Rui Wang
• Allele ID: MGI:8288700
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(MMTV-PyVT)634Mul/0 Tmem25^tm1.1Hrwa/Tmem25^tm1.1Hrwa	FVB.Cg-Tmem25^tm1.1Hrwa Tg(MMTV-PyVT)634Mul	MGI:8288738

Genotype
MGI:8288738

cx1

• Allelic Composition: Tg(MMTV-PyVT)634Mul/0; Tmem25^tm1.1Hrwa/Tmem25^tm1.1Hrwa
• Genetic Background: FVB.Cg-Tmem25^tm1.1Hrwa Tg(MMTV-PyVT)634Mul

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:335171 )

♀ • mice show drastic promotion of triple-negative breast tumor growth and lung metastasis compared to single Tg(MMTV-PyVT)634Mul/0 mice

increased metastatic potential ( J:335171 )

♀ • mice show increased triple-negative breast tumor lung metastasis compared to single Tg(MMTV-PyVT)634Mul/0 mice

♀ • the normalized lung metastasis to primary tumor burden is increased

increased tumor cell proliferation ( J:335171 )

♀ • cell proliferation is increased in spontaneous breast tumors

mortality/aging

decreased tumor-free survival time ( J:335171 )

♀ • overall survival time is shortened compared to single Tg(MMTV-PyVT)634Mul/0 mice

integument

increased mammary gland tumor incidence ( J:335171 )

♀ • mice show drastic promotion of triple-negative breast tumor growth and lung metastasis compared to single Tg(MMTV-PyVT)634Mul/0 mice

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:335171 )

♀ • mice show drastic promotion of triple-negative breast tumor growth and lung metastasis compared to single Tg(MMTV-PyVT)634Mul/0 mice