Tmem25^tm1.1Hrwa
Targeted Allele Detail

Summary

• Symbol: Tmem25^tm1.1Hrwa
• Name: transmembrane protein 25; targeted mutation 1.1, Hong-Rui Wang
• MGI ID: MGI:8288700
• Gene: Tmem25 Location: Chr9:44705066-44710604 bp, - strand Genetic Position: Chr9, 24.84 cM
• Alliance: Tmem25^tm1.1Hrwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:335171
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2 and an FRT-flanked neomycin selection cassette and second loxP site downstream of exon 5. Exons 2 to 5 and the neomycin cassette were removed via cre-mediated recombination in the germline. (J:335171)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tmem25 Mutation: 22 strains or lines available

References

• Original: J:335171 Bi J, et al., TMEM25 inhibits monomeric EGFR-mediated STAT3 activation in basal state to suppress triple-negative breast cancer progression. Nat Commun. 2023 Apr 24;14(1):2342
• All: 1 reference(s)