All Phenotypes Slc25a47<em1Lchen> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc25a47^em1Lchen/Slc25a47^em1Lchen	B6.Cg-Slc25a47^em1Lchen	MGI:8286373
cx2	Lep^ob/Lep^ob Slc25a47^em1Lchen/Slc25a47^em1Lchen	involves: C57BL/6J * C57BL/10J	MGI:8286376

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:338255 )

• increased mortality following treatment with DEN compared to treatment matched wild-type controls

liver/biliary system

abnormal hepatocyte respiration ( J:338255 )

• increased contribution of amino acids to mitochondrial respiration in primary hepatocytes

• increase in the efficiency of use of glutamine in primary hepatocytes

increased liver cholesterol level ( J:338255 )

• in primary hepatocytes

increased liver triglyceride level ( J:338255 )

• in primary hepatocytes

abnormal hepatocyte morphology ( J:338255 )

• increased number of lipid droplets in primary hepatocytes

increased liver tumor incidence ( J:338255 )

• liver tumors are found in 77.8% of mice at 20 months of age compared to no visible tumors in age matched wild-type controls

increased susceptibility to diet-induced hepatic steatosis ( J:338255 )

• significantly increased high-fat diet induced hepatic steatosis compared to diet matched controls

neoplasm

increased incidence of tumors by chemical induction ( J:338255 )

• increased incidence of DEN induced hepatocellular carcinomas

• 97.5% increase in the liver index and 2.41-fold higher incidence of tumor nodules in DEN treated mice compared to treatment matched wild-type controls

• significant lipid accumulation of lipids in tumor nodules

increased liver tumor incidence ( J:338255 )

• liver tumors are found in 77.8% of mice at 20 months of age compared to no visible tumors in age matched wild-type controls

cellular

abnormal hepatocyte respiration ( J:338255 )

• increased contribution of amino acids to mitochondrial respiration in primary hepatocytes

• increase in the efficiency of use of glutamine in primary hepatocytes

abnormal mitochondrial physiology ( J:338255 )

• uptake of NAD+ and acetyl-CoA are reduced by 45.9% and 53.6% in liver mitochondria compared to wild-type controls

• however, uptake of adenosine and flavin adenine dinucleotide are similar to controls

homeostasis/metabolism

increased liver cholesterol level ( J:338255 )

• in primary hepatocytes

increased liver triglyceride level ( J:338255 )

• in primary hepatocytes

increased susceptibility to xenobiotic induced morbidity/mortality ( J:338255 )

• increased mortality following treatment with DEN compared to treatment matched wild-type controls

increased incidence of tumors by chemical induction ( J:338255 )

• increased incidence of DEN induced hepatocellular carcinomas

• 97.5% increase in the liver index and 2.41-fold higher incidence of tumor nodules in DEN treated mice compared to treatment matched wild-type controls

• significant lipid accumulation of lipids in tumor nodules

Allelic Composition	Lep^ob/Lep^ob Slc25a47^em1Lchen/Slc25a47^em1Lchen
Genetic Background	involves: C57BL/6J * C57BL/10J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lep^ob mutation (5 available); any Lep mutation (19 available)
Slc25a47^em1Lchen mutation (0 available); any Slc25a47 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

increased liver weight ( J:338255 )

• increased weight compared to mutant mice wild-type for Slc25a47 at 12 weeks of age

increased liver cholesterol level ( J:338255 )