Slc25a47^em1Lchen
Allele Detail

Summary

• Symbol: Slc25a47^em1Lchen
• Name: solute carrier family 25, member 47; endonuclease-mediated mutation 1, Ligong Chen
• MGI ID: MGI:8282761
• Gene: Slc25a47 Location: Chr12:108815740-108822741 bp, + strand Genetic Position: Chr12, 59.65 cM
• Alliance: Slc25a47^em1Lchen page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Not Specified (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9-mediated recombination resulted in a 5 bp deletion (ACACG) after the codon for amino acid 41 creating a premature stop codon at amino acid 95 in exon 4. (J:338255)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc25a47 Mutation: 15 strains or lines available

References

• Original: J:338255 Cheng L, et al., Hepatic mitochondrial NAD + transporter SLC25A47 activates AMPKalpha mediating lipid metabolism and tumorigenesis. Hepatology. 2023 Feb 22
• All: 1 reference(s)