All Phenotypes Smc3<tm1.1Toshi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Smc3^tm1.1Toshi
targeted mutation 1.1, Toshihide Yamashita
MGI:7384685

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Smc3^tm1.1Toshi/Smc3^tm1.1Toshi H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	B6.Cg-H2az2^{Tg(Wnt1-cre)11Rth} Smc3^tm1.1Toshi	MGI:7489843
cn2	Smc3^tm1.1Toshi/Smc3^tm1.1Toshi Tg(Nes-cre/ERT2)#Kag/0	involves: C57BL/6 * C57BL/6J	MGI:7489857
cn3	Smc3^tm1.1Toshi/Smc3^tm1.1Toshi Mapt^tm2(cre)Aha/?	involves: C57BL/6J	MGI:7489850
cn4	Smc3^tm1.1Toshi/Smc3⁺ Mapt^tm2(cre)Aha/Mapt⁺	involves: C57BL/6J	MGI:7489855
cn5	Smc3^tm1.1Toshi/Smc3⁺ Tg(Icam5-cre)DYyos/0	involves: C57BL/6J * DBA/2J	MGI:7489862

Allelic Composition	Smc3^tm1.1Toshi/Smc3^tm1.1Toshi H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	B6.Cg-H2az2^{Tg(Wnt1-cre)11Rth} Smc3^tm1.1Toshi

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (25 available)
Smc3^tm1.1Toshi mutation (0 available); any Smc3 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

small cranium ( J:242006 )

• at P0.5, mice exhibit a significantly smaller skull than control mice

cleft palate ( J:242006 )

• at E17.5, mice exhibit a cleft palate

skeleton

small cranium ( J:242006 )

• at P0.5, mice exhibit a significantly smaller skull than control mice

growth/size/body

cleft palate ( J:242006 )

• at E17.5, mice exhibit a cleft palate

digestive/alimentary system

cleft palate ( J:242006 )

• at E17.5, mice exhibit a cleft palate

Allelic Composition	Smc3^tm1.1Toshi/Smc3^tm1.1Toshi Tg(Nes-cre/ERT2)#Kag/0
Genetic Background	involves: C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smc3^tm1.1Toshi mutation (0 available); any Smc3 mutation (46 available)
Tg(Nes-cre/ERT2)#Kag mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

enlarged brain ventricles ( J:242006 )

• mice treated with tamoxifen at E10.5 and fixed with PFA at E18.5 exhibit enlarged ventricles

Allelic Composition	Smc3^tm1.1Toshi/Smc3^tm1.1Toshi Mapt^tm2(cre)Aha/?
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapt^tm2(cre)Aha mutation (0 available); any Mapt mutation (453 available)
Smc3^tm1.1Toshi mutation (0 available); any Smc3 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:242006 )

• mice die by 5 weeks of age

growth/size/body

decreased body size ( J:242006 )

• mice are significantly smaller than controls

postnatal growth retardation ( J:242006 )

Allelic Composition	Smc3^tm1.1Toshi/Smc3⁺ Mapt^tm2(cre)Aha/Mapt⁺
Genetic Background	involves: C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased anxiety-related response ( J:242006 )

• in the novelty-induced hypophagia test, adult males show a significantly longer latency to drink milk in a novel, brightly lit cage as well as reduced milk consumption relative to controls, indicating increased anxiety

• however, no significant differences are noted in the light/dark transition or marble-burying tests

nervous system

decreased CNS synapse formation ( J:242006 )

• at P21, Stat1 expression in the cortex is significantly higher than in controls

Allelic Composition	Smc3^tm1.1Toshi/Smc3⁺ Tg(Icam5-cre)DYyos/0
Genetic Background	involves: C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smc3^tm1.1Toshi mutation (0 available); any Smc3 mutation (46 available)
Tg(Icam5-cre)DYyos mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal pyramidal neuron dendrite morphology ( J:242006 )

• at 6 weeks of age, cortical layer II/III pyramidal neurons exhibit greater dendritic arbor complexity and dendrite length than in control mice

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