Tg(Nes-cre/ERT2)#Kag
Transgene Detail

Summary

• Symbol: Tg(Nes-cre/ERT2)#Kag
• Name: transgene insertion, Ryoichiro Kageyama
• MGI ID: MGI:4941327
• Synonyms: Nestin-CreER^T2
• Transgene: Tg(Nes-cre/ERT2)#Kag Location: unknown
• Alliance: Tg(Nes-cre/ERT2)#Kag page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Nes-cre/ERT2)#Kag expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Nes (25491)

  Nes	(MGI:101784)

• Mutation details: This transgene consists of a 5.8 kb fragment of the rat Nes promoter and a 1.8 kb fragment of the second intron of Nes driving expression of a tamoxifen-inducible form of cre recombinase followed by an SV40 poly A sequence. Three lines were created (lines 1, 4, and 5-1) with differing levels of activity (high, medium, and low, respectively) and leakiness (high, low and none, respectively). The pound symbol (#) is used to indicate that no line was specified or that lines were pooled. (J:110145)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Nes (rat) Summary of all recombinase alleles driven by Nes. Alliance rat Nes gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:169319 Muraguchi T, et al., NKX2.2 suppresses self-renewal of glioma-initiating cells. Cancer Res. 2011 Feb 1;71(3):1135-45
• All: 45 reference(s)