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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Aldh1a2tm1.1Mbp
targeted mutation 1.1, Mouse Biology Program, UC Davis
MGI:7327620
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Aldh1a1tm1Gdu/Aldh1a1tm1Gdu
Aldh1a2tm1.1Mbp/Aldh1a2tm1.2Mbp
Plekha5Tg(AMH-cre)1Flor/Plekha5+ 		involves: 129 * C57BL/6 * SJL MGI:7327644
cn2
 		Aldh1a1tm1Gdu/Aldh1a1tm1Gdu
Aldh1a2tm1.1Mbp/Aldh1a2tm1.1Mbp
Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+ 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 MGI:7327640
cn3
 		Aldh1a1tm1Gdu/Aldh1a1tm1Gdu
Aldh1a2tm1.1Mbp/Aldh1a2tm1.2Mbp
Tg(Stra8-icre)1Reb/0 		involves: 129 * C57BL/6 * FVB/NJ MGI:7327642


Genotype
MGI:7327644
cn1
Allelic
Composition		 Aldh1a1tm1Gdu/Aldh1a1tm1Gdu
Aldh1a2tm1.1Mbp/Aldh1a2tm1.2Mbp
Plekha5Tg(AMH-cre)1Flor/Plekha5+
Genetic
Background		 involves: 129 * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aldh1a1tm1Gdu mutation (1 available); any Aldh1a1 mutation (37 available)
Aldh1a2tm1.1Mbp mutation (0 available); any Aldh1a2 mutation (36 available)
Aldh1a2tm1.2Mbp mutation (0 available); any Aldh1a2 mutation (36 available)
Plekha5Tg(AMH-cre)1Flor mutation (1 available); any Plekha5 mutation (109 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal spermatogenesis ( J:324715 )
• block at the progression at the conversion of A spermatogonia to A1
• however, injection with retinoic acid restored spermatogenesis

endocrine/exocrine glands

cellular




Genotype
MGI:7327640
cn2
Allelic
Composition		 Aldh1a1tm1Gdu/Aldh1a1tm1Gdu
Aldh1a2tm1.1Mbp/Aldh1a2tm1.1Mbp
Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aldh1a1tm1Gdu mutation (1 available); any Aldh1a1 mutation (37 available)
Aldh1a2tm1.1Mbp mutation (0 available); any Aldh1a2 mutation (36 available)
Gt(ROSA)26Sortm1(cre/ERT2)Tyj mutation (3 available); any Gt(ROSA)26Sor mutation (944 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal spermatogenesis ( J:324715 )
• block at the progression at the conversion of A spermatogonia to A1 following chronic treatment with tamoxifen
azoospermia ( J:324715 )
• sperm depletion occurs after chronic administration of tamoxifen

cellular
azoospermia ( J:324715 )
• sperm depletion occurs after chronic administration of tamoxifen




Genotype
MGI:7327642
cn3
Allelic
Composition		 Aldh1a1tm1Gdu/Aldh1a1tm1Gdu
Aldh1a2tm1.1Mbp/Aldh1a2tm1.2Mbp
Tg(Stra8-icre)1Reb/0
Genetic
Background		 involves: 129 * C57BL/6 * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aldh1a1tm1Gdu mutation (1 available); any Aldh1a1 mutation (37 available)
Aldh1a2tm1.1Mbp mutation (0 available); any Aldh1a2 mutation (36 available)
Aldh1a2tm1.2Mbp mutation (0 available); any Aldh1a2 mutation (36 available)
Tg(Stra8-icre)1Reb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:324715 )
N
• male mice exhibit normal spermatogenesis




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory