All Phenotypes Cc2d1a<tm1.1Thkn> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cc2d1a^tm1.1Thkn
targeted mutation 1.1, Thomas Klein
MGI:6458916

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cc2d1a^tm1.1Thkn/Cc2d1a^tm1.1Thkn	involves: 129S4/SvJae * C57BL/6 * SJL	MGI:6459278
cn2	Cc2d1a^tm1.1Thkn/Cc2d1a^tm1.1Thkn Hes1^tm1.1Sat/Hes1⁺ Tg(Vil1-cre)997Gum/0	involves: 129S4/SvJae * C57BL/6NTac * SJL	MGI:6459274
cn3	Cc2d1a^tm1.1Thkn/Cc2d1a^tm1.1Thkn Tg(Vil1-cre)997Gum/0	involves: 129S4/SvJae * C57BL/6 * SJL	MGI:6459275
cn4	Cc2d1a^tm1.1Thkn/Cc2d1a^tm1.1Thkn Tg(Nes-cre)1Kln/0	involves: 129S4/SvJae * C57BL/6 * SJL	MGI:6459277

Allelic Composition	Cc2d1a^tm1.1Thkn/Cc2d1a^tm1.1Thkn
Genetic Background	involves: 129S4/SvJae * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cc2d1a^tm1.1Thkn mutation (0 available); any Cc2d1a mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:236761 )

• mice are viable, fertile and do not display any obvious phenotype

Allelic Composition	Cc2d1a^tm1.1Thkn/Cc2d1a^tm1.1Thkn Hes1^tm1.1Sat/Hes1⁺ Tg(Vil1-cre)997Gum/0
Genetic Background	involves: 129S4/SvJae * C57BL/6NTac * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cc2d1a^tm1.1Thkn mutation (0 available); any Cc2d1a mutation (32 available)
Hes1^tm1.1Sat mutation (0 available); any Hes1 mutation (21 available)
Tg(Vil1-cre)997Gum mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

digestive/alimentary phenotype ( J:236761 )

N	• mice exhibit normal intestinal Notch signaling

Allelic Composition	Cc2d1a^tm1.1Thkn/Cc2d1a^tm1.1Thkn Tg(Vil1-cre)997Gum/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cc2d1a^tm1.1Thkn mutation (0 available); any Cc2d1a mutation (32 available)
Tg(Vil1-cre)997Gum mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

digestive/alimentary phenotype ( J:236761 )

N	• mice exhibit normal intestine morphology

Allelic Composition	Cc2d1a^tm1.1Thkn/Cc2d1a^tm1.1Thkn Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cc2d1a^tm1.1Thkn mutation (0 available); any Cc2d1a mutation (32 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:236761 )

• Background Sensitivity: all mice on a mixed background die within 12 hours of birth compared with mice on a background with increased C57BL/6 that die at birth

respiratory system

respiratory distress ( J:236761 )

• severe in 4 of 12 mice at birth

homeostasis/metabolism

cyanosis ( J:236761 )

• Background Sensitivity: in 4 of 12 mice on a mixed background at birth compared with 5 of 5 mice on a background with increased C57BL/6

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23