About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mapkapk2tm1.1Gkl
targeted mutation 1.1, George Kollias
MGI:6357678
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Mapkapk2tm1.1Gkl/Mapkapk2tm1.1Gkl
Tg(Tie1-cre)9Ref/0 		involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J MGI:6357719
cn2
 		ApcMin/Apc+
Mapkapk2tm1.1Gkl/Mapkapk2tm1.1Gkl
Tg(Tie1-cre)9Ref/0 		involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J MGI:6357721
cn3
 		Mapkapk2tm1.1Gkl/Mapkapk2tm1.1Gkl
Twist2tm1.1(cre)Dor/Twist2+ 		involves: 129X1/SvJ * BALB/cJ * C57BL/6 MGI:6357718
cn4
 		ApcMin/Apc+
Mapkapk2tm1.1Gkl/Mapkapk2tm1.1Gkl
Twist2tm1.1(cre)Dor/Twist2+ 		involves: 129X1/SvJ * BALB/cJ * C57BL/6J MGI:6357723


Genotype
MGI:6357719
cn1
Allelic
Composition		 Mapkapk2tm1.1Gkl/Mapkapk2tm1.1Gkl
Tg(Tie1-cre)9Ref/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapkapk2tm1.1Gkl mutation (1 available); any Mapkapk2 mutation (35 available)
Tg(Tie1-cre)9Ref mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased incidence of tumors by chemical induction ( J:262876 )
• smaller tumors induced by AOM/DSS
• however, development of induced colitis is normal

neoplasm
decreased incidence of tumors by chemical induction ( J:262876 )
• smaller tumors induced by AOM/DSS
• however, development of induced colitis is normal




Genotype
MGI:6357721
cn2
Allelic
Composition		 ApcMin/Apc+
Mapkapk2tm1.1Gkl/Mapkapk2tm1.1Gkl
Tg(Tie1-cre)9Ref/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (151 available)
Mapkapk2tm1.1Gkl mutation (1 available); any Mapkapk2 mutation (35 available)
Tg(Tie1-cre)9Ref mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor cell death ( J:262876 )
• increased apoptosis of tumor cells compared to in Apcmin heterozygotes
decreased tumor cell proliferation ( J:262876 )
• reduced proliferation of tumor cells compared to in Apcmin heterozygotes




Genotype
MGI:6357718
cn3
Allelic
Composition		 Mapkapk2tm1.1Gkl/Mapkapk2tm1.1Gkl
Twist2tm1.1(cre)Dor/Twist2+
Genetic
Background		 involves: 129X1/SvJ * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapkapk2tm1.1Gkl mutation (1 available); any Mapkapk2 mutation (35 available)
Twist2tm1.1(cre)Dor mutation (1 available); any Twist2 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased incidence of tumors by chemical induction ( J:262876 )
• fewer smaller tumors induced by AOM/DSS
• however, development of induced colitis is normal

homeostasis/metabolism
decreased incidence of tumors by chemical induction ( J:262876 )
• fewer smaller tumors induced by AOM/DSS
• however, development of induced colitis is normal




Genotype
MGI:6357723
cn4
Allelic
Composition		 ApcMin/Apc+
Mapkapk2tm1.1Gkl/Mapkapk2tm1.1Gkl
Twist2tm1.1(cre)Dor/Twist2+
Genetic
Background		 involves: 129X1/SvJ * BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (151 available)
Mapkapk2tm1.1Gkl mutation (1 available); any Mapkapk2 mutation (35 available)
Twist2tm1.1(cre)Dor mutation (1 available); any Twist2 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor cell death ( J:262876 )
• increased apoptosis of tumor cells compared with Apcmin heterozygotes
decreased tumor cell proliferation ( J:262876 )
• reduced proliferation of tumor cells compared with Apcmin heterozygotes
decreased tumor growth/size ( J:262876 )
• compared with Apcmin heterozygotes
decreased tumor incidence ( J:262876 )
• compared with Apcmin heterozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory