Phenotypes associated with this allele

• Allele Symbol: Fbn2^{em1(IMPC)Rbrc}
• Allele Name: endonuclease-mediated mutation 1, RIKEN BioResource Center
• Allele ID: MGI:6257481
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fbn2^em1(IMPC)Rbrc/Fbn2^em1(IMPC)Rbrc	C57BL/6NJcl-Fbn2^em1(IMPC)Rbrc/Rbrc	MGI:7414891

Genotype
MGI:7414891

hm1

• Allelic Composition: Fbn2^{em1(IMPC)Rbrc}/Fbn2^{em1(IMPC)Rbrc}
• Genetic Background: C57BL/6NJcl-Fbn2^{em1(IMPC)Rbrc}/Rbrc

Data Sources

IMPC Data for Fbn2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased anxiety-related response ( J:211773 )

IMPC - RBRC

decreased grip strength ( J:211773 )

IMPC - RBRC

abnormal gait ( J:211773 )

IMPC - RBRC

hyperactivity ( J:211773 )

IMPC - RBRC

cardiovascular system

abnormal heart morphology ( J:211773 )

IMPC - RBRC

abnormal heart weight ( J:211773 )

♀

IMPC - RBRC

enlarged heart ( J:211773 )

IMPC - RBRC

prolonged ST segment ( J:211773 )

IMPC - RBRC

cornea vascularization ( J:211773 )

♀

IMPC - RBRC

craniofacial

abnormal cranium morphology ( J:211773 )

IMPC - RBRC

abnormal mandible morphology ( J:211773 )

IMPC - RBRC

abnormal zygomatic bone morphology ( J:211773 )

IMPC - RBRC

growth/size/body

enlarged heart ( J:211773 )

IMPC - RBRC

abnormal mandible morphology ( J:211773 )

IMPC - RBRC

abnormal zygomatic bone morphology ( J:211773 )

IMPC - RBRC

decreased body length ( J:211773 )

IMPC - RBRC

hematopoietic system

thrombocytopenia ( J:211773 )

♂

IMPC - RBRC

homeostasis/metabolism

increased circulating alkaline phosphatase level ( J:211773 )

♀

IMPC - RBRC

decreased circulating amylase level ( J:211773 )

IMPC - RBRC

integument

abnormal nail morphology ( J:211773 )

IMPC - RBRC

abnormal skin morphology ( J:211773 )

IMPC - RBRC

limbs/digits/tail

abnormal autopod morphology ( J:211773 )

IMPC - RBRC

abnormal digit morphology ( J:211773 )

IMPC - RBRC

syndactyly ( J:211773 )

IMPC - RBRC

abnormal humerus morphology ( J:211773 )

IMPC - RBRC

abnormal radius morphology ( J:211773 )

IMPC - RBRC

abnormal ulna morphology ( J:211773 )

IMPC - RBRC

abnormal femur morphology ( J:211773 )

IMPC - RBRC

abnormal fibula morphology ( J:211773 )

IMPC - RBRC

abnormal tibia morphology ( J:211773 )

IMPC - RBRC

abnormal tail morphology ( J:211773 )

IMPC - RBRC

liver/biliary system

abnormal liver morphology ( J:211773 )

IMPC - RBRC

nervous system

abnormal brain morphology ( J:211773 )

IMPC - RBRC

abnormal optic disk morphology ( J:211773 )

♂

IMPC - RBRC

renal/urinary system

abnormal kidney morphology ( J:211773 )

IMPC - RBRC

skeleton

abnormal cranium morphology ( J:211773 )

IMPC - RBRC

abnormal mandible morphology ( J:211773 )

IMPC - RBRC

abnormal zygomatic bone morphology ( J:211773 )

IMPC - RBRC

abnormal humerus morphology ( J:211773 )

IMPC - RBRC

abnormal radius morphology ( J:211773 )

IMPC - RBRC

abnormal ulna morphology ( J:211773 )

IMPC - RBRC

abnormal femur morphology ( J:211773 )

IMPC - RBRC

abnormal fibula morphology ( J:211773 )

IMPC - RBRC

abnormal tibia morphology ( J:211773 )

IMPC - RBRC

abnormal clavicle morphology ( J:211773 )

IMPC - RBRC

abnormal pelvic girdle bone morphology ( J:211773 )

IMPC - RBRC

abnormal rib morphology ( J:211773 )

♀

IMPC - RBRC

abnormal vertebral arch morphology ( J:211773 )

IMPC - RBRC

abnormal bone structure ( J:211773 )

♀

IMPC - RBRC

increased bone mineral content ( J:211773 )

♂

IMPC - RBRC

abnormal joint morphology ( J:211773 )

IMPC - RBRC

vertebral fusion ( J:211773 )

IMPC - RBRC

vision/eye

abnormal eye morphology ( J:211773 )

IMPC - RBRC

cornea vascularization ( J:211773 )

♀

IMPC - RBRC

abnormal optic disk morphology ( J:211773 )

♂

IMPC - RBRC

cornea opacity ( J:211773 )

IMPC - RBRC