All Phenotypes Gt(ROSA)26Sor<tm1(CAG-MYCN,-luc)Jhsc> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^{tm1(CAG-MYCN,-luc)Jhsc}/Gt(ROSA)26Sor⁺ Pten^tm2.1Ppp/Pten^tm2.1Ppp Rb1^tm2Brn/Rb1^tm2Brn Tg(Pbsn-cre)4Prb/0	involves: 129 * 129S1/Sv * 129S6/SvEvTac * C57BL/6 * DBA/2	MGI:7277819
cn2	Gt(ROSA)26Sor^{tm1(CAG-MYCN,-luc)Jhsc}/Gt(ROSA)26Sor⁺ Pten^tm2.1Ppp/Pten^tm2.1Ppp Rb1^tm2Brn/Rb1⁺ Tg(Pbsn-cre)4Prb/0	involves: 129 * 129S1/Sv * 129S6/SvEvTac * C57BL/6 * DBA/2	MGI:7277820
cn3	Gt(ROSA)26Sor^{tm1(CAG-MYCN,-luc)Jhsc}/Gt(ROSA)26Sor⁺ Pten^tm2.1Ppp/Pten^tm2.1Ppp Tg(Pbsn-cre)4Prb/0	involves: 129 * 129S1/Sv * 129S6/SvEvTac * C57BL/6 * DBA/2	MGI:7277821
cn4	Gt(ROSA)26Sor^{tm1(CAG-MYCN,-luc)Jhsc}/Gt(ROSA)26Sor⁺ Tg(Dbh-icre)1Gsc/0	involves: 129S6/SvEvTac * C57BL/6	MGI:6196129

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:307910 )

• median survival time of 12.5 weeks

• castrated mice have a median survival time of 24 weeks

neoplasm

increased prostate gland tumor incidence ( J:307910 )

• mice develop large, invasive prostate tumors with androgen receptor (AR)-negative and poorly differentiated foci as early as 8 weeks

• these regions show little resemblance to conventional adenocarcinoma but are negative for neuroendocrine markers, potentially as a transition between conventional adenocarcinoma and neuroendocrine prostate cancer (NEPC) states

• some foci are positive for neuroendocrine markers INSM1, EZH2, and NKX2-1 and some foci display condensed nuclei and scant cytoplasm, characteristic of NEPC morphology

• tumors also include other foci of divergent differentiation like intestinal and squamous, as well as conventional, AR+ adenocarcinoma, but the percentage of conventional adenocarcinoma decreases over time while the percentage of poorly differentiated histology increases over time

• mice do not respond to surgical castration and continue to grow tumors rapidly

• post-castration tumors harbor foci enriched with divergent differentiated histology compared to adenocarcinoma and increased metastatic potential

increased metastatic potential ( J:307910 )

• onset of metastasis occurs as early as 8 weeks and by 12 weeks, 100% of mice develop distant metastatic lesions; metastases to the lung, liver, lymph nodes, and kidney primarily consist of large and small cell neuroendocrine histologies that are AR-negative

endocrine/exocrine glands

increased prostate gland tumor incidence ( J:307910 )

• mice develop large, invasive prostate tumors with androgen receptor (AR)-negative and poorly differentiated foci as early as 8 weeks

• some foci are positive for neuroendocrine markers INSM1, EZH2, and NKX2-1 and some foci display condensed nuclei and scant cytoplasm, characteristic of NEPC morphology

• mice do not respond to surgical castration and continue to grow tumors rapidly

• post-castration tumors harbor foci enriched with divergent differentiated histology compared to adenocarcinoma and increased metastatic potential

reproductive system

increased prostate gland tumor incidence ( J:307910 )

• mice develop large, invasive prostate tumors with androgen receptor (AR)-negative and poorly differentiated foci as early as 8 weeks

• some foci are positive for neuroendocrine markers INSM1, EZH2, and NKX2-1 and some foci display condensed nuclei and scant cytoplasm, characteristic of NEPC morphology

• mice do not respond to surgical castration and continue to grow tumors rapidly

• post-castration tumors harbor foci enriched with divergent differentiated histology compared to adenocarcinoma and increased metastatic potential

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate neuroendocrine neoplasm		DOID:2992		J:307910

Allelic Composition	Gt(ROSA)26Sor^{tm1(CAG-MYCN,-luc)Jhsc}/Gt(ROSA)26Sor⁺ Pten^tm2.1Ppp/Pten^tm2.1Ppp Rb1^tm2Brn/Rb1⁺ Tg(Pbsn-cre)4Prb/0
Genetic Background	involves: 129 * 129S1/Sv * 129S6/SvEvTac * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(CAG-MYCN,-luc)Jhsc} mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Pten^tm2.1Ppp mutation (0 available); any Pten mutation (81 available)
Rb1^tm2Brn mutation (3 available); any Rb1 mutation (106 available)
Tg(Pbsn-cre)4Prb mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:307910 )

• median survival time of 19 weeks

neoplasm

increased prostate gland tumor incidence ( J:307910 )

• mice develop large, invasive tumors with androgen receptor (AR)-negative and poorly differentiated foci as early as 12 weeks

• some foci are positive for neuroendocrine markers INSM1, EZH2, and NKX2-1 and some foci display condensed nuclei and scant cytoplasm, characteristic of NEPC morphology

endocrine/exocrine glands

increased prostate gland tumor incidence ( J:307910 )

• mice develop large, invasive tumors with androgen receptor (AR)-negative and poorly differentiated foci as early as 12 weeks

• some foci are positive for neuroendocrine markers INSM1, EZH2, and NKX2-1 and some foci display condensed nuclei and scant cytoplasm, characteristic of NEPC morphology

reproductive system

increased prostate gland tumor incidence ( J:307910 )

• mice develop large, invasive tumors with androgen receptor (AR)-negative and poorly differentiated foci as early as 12 weeks

• some foci are positive for neuroendocrine markers INSM1, EZH2, and NKX2-1 and some foci display condensed nuclei and scant cytoplasm, characteristic of NEPC morphology

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate neuroendocrine neoplasm		DOID:2992		J:307910

Allelic Composition	Gt(ROSA)26Sor^{tm1(CAG-MYCN,-luc)Jhsc}/Gt(ROSA)26Sor⁺ Pten^tm2.1Ppp/Pten^tm2.1Ppp Tg(Pbsn-cre)4Prb/0
Genetic Background	involves: 129 * 129S1/Sv * 129S6/SvEvTac * C57BL/6 * DBA/2

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:307910 )

• median survival time of 26 weeks

• castrated mice have a median survival time of 44 weeks

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:307910 )

• mice develop prostate tumors that have primarily high-grade prostatic intraepithelial neoplasia at earlier time points

• tumors regress post-castration but resume growth 24 weeks post-castration

endocrine/exocrine glands

increased prostate intraepithelial neoplasia incidence ( J:307910 )

• mice develop prostate tumors that have primarily high-grade prostatic intraepithelial neoplasia at earlier time points

• tumors regress post-castration but resume growth 24 weeks post-castration

reproductive system

increased prostate intraepithelial neoplasia incidence ( J:307910 )

• mice develop prostate tumors that have primarily high-grade prostatic intraepithelial neoplasia at earlier time points

• tumors regress post-castration but resume growth 24 weeks post-castration

Allelic Composition	Gt(ROSA)26Sor^{tm1(CAG-MYCN,-luc)Jhsc}/Gt(ROSA)26Sor⁺ Tg(Dbh-icre)1Gsc/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased neuroblastoma incidence ( J:222527 )

• mice develop abdominal tumors with an incidence of 76%

• tumor onset occurs between 26-337 days of age, with a mean age of 79.6 days

• tumors arise from the superior cervical ganglion, the adrenals, or the celiac ganglion

• histology indicates small round cell tumor with cells harboring neurosecretory vesicles and express markers indicative of neuroblastoma

• neuroblastomas are characterized by genomic aberrations syntenic to human neuroblastomas

endocrine/exocrine glands

adrenal medulla hyperplasia ( J:222527 )

• hyperplastic cells are present in the adrenal medulla of some adrenal glands in 0-day old pups and most 14 and 28 day old mice

• at 28 days of age, the adrenal medulla has an atypical, nodal tissue architecture

nervous system

increased neuroblastoma incidence ( J:222527 )

• mice develop abdominal tumors with an incidence of 76%

• tumor onset occurs between 26-337 days of age, with a mean age of 79.6 days

• tumors arise from the superior cervical ganglion, the adrenals, or the celiac ganglion

• histology indicates small round cell tumor with cells harboring neurosecretory vesicles and express markers indicative of neuroblastoma

• neuroblastomas are characterized by genomic aberrations syntenic to human neuroblastomas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
neuroblastoma		DOID:769		J:222527

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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