About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fbxw7tm1Iken
targeted mutation 1, Tsuneo Ikenoue
MGI:6157075
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Fbxw7tm1Iken/Fbxw7+
Krastm4Tyj/Kras+
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA MGI:6157295
cn2
 		Fbxw7tm1Iken/Fbxw7tm1Iken
Krastm4Tyj/Kras+
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA MGI:6157296
cn3
 		Fbxw7tm1Iken/Fbxw7tm1Iken
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: C57BL/6 * C57BL/6N * DBA MGI:6157293


Genotype
MGI:6157295
cn1
Allelic
Composition		 Fbxw7tm1Iken/Fbxw7+
Krastm4Tyj/Kras+
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxw7tm1Iken mutation (0 available); any Fbxw7 mutation (81 available)
Krastm4Tyj mutation (11 available); any Kras mutation (69 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
bile duct hyperplasia ( J:258194 )
• bile duct hyperplasia is seen in some mice at 8 months of age
dilated bile duct ( J:258194 )
• bile duct dilation is seen in some mice at 8 months of age

liver/biliary system
bile duct hyperplasia ( J:258194 )
• bile duct hyperplasia is seen in some mice at 8 months of age
dilated bile duct ( J:258194 )
• bile duct dilation is seen in some mice at 8 months of age




Genotype
MGI:6157296
cn2
Allelic
Composition		 Fbxw7tm1Iken/Fbxw7tm1Iken
Krastm4Tyj/Kras+
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * C57BL/6N * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxw7tm1Iken mutation (0 available); any Fbxw7 mutation (81 available)
Krastm4Tyj mutation (11 available); any Kras mutation (69 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
increased cholangiocarcinoma incidence ( J:258194 )
• all mice develop cholangiocarcinoma-like lesions composed of dysplastic dust-like structures surrounded by fibrosis within 2 months of birth

neoplasm
increased cholangiocarcinoma incidence ( J:258194 )
• all mice develop cholangiocarcinoma-like lesions composed of dysplastic dust-like structures surrounded by fibrosis within 2 months of birth

endocrine/exocrine glands
increased cholangiocarcinoma incidence ( J:258194 )
• all mice develop cholangiocarcinoma-like lesions composed of dysplastic dust-like structures surrounded by fibrosis within 2 months of birth




Genotype
MGI:6157293
cn3
Allelic
Composition		 Fbxw7tm1Iken/Fbxw7tm1Iken
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: C57BL/6 * C57BL/6N * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxw7tm1Iken mutation (0 available); any Fbxw7 mutation (81 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
bile duct hyperplasia ( J:258194 )
• hyperplasia of bile ducts throughout the liver at 12 months of age
dilated bile duct ( J:258194 )
• dilatation of bile ducts throughout the liver at 12 months of age

liver/biliary system
bile duct hyperplasia ( J:258194 )
• hyperplasia of bile ducts throughout the liver at 12 months of age
dilated bile duct ( J:258194 )
• dilatation of bile ducts throughout the liver at 12 months of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory