All Phenotypes Fnip1<m1Btlr> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fnip1^m1Btlr/Fnip1^m1Btlr	C57BL/6J-Fnip1^m1Btlr	MGI:5806736
cn2	Fnip1^m1Btlr/Fnip1^m1Btlr Prkag2^tm1.1Geno/Prkag2^tm1.1Geno Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺	involves: 129 * C57BL/6 * C57BL/6J * CBA	MGI:6116217
cn3	Atg3^tm1.1Ywh/Atg3^tm1.1Ywh Fnip1^m1Btlr/Fnip1^m1Btlr Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:5806734

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:234285 )

N	• mice exhibit normal left ventricle systolic function and corrected QT interval

increased cardiac muscle glycogen level ( J:234285 )

enlarged heart ( J:234285 )

cardiac hypertrophy ( J:234285 )

shortened PR interval ( J:234285 )

prolonged QRS complex duration ( J:234285 )

immune system

decreased marginal zone B cell number ( J:234285 )

• reduced marginal zone B cells and marginal zone precursor compartments

• however, transitional and follicular B cell subsets are normal

absent B cells ( J:234285 )

• in the peritoneum and spleen

• Tg(BCL2)25Wehi expression or Trp53^tm1Tyj deficiency does not correct peripheral B cell numbers

abnormal splenocyte morphology ( J:234285 )

• reduced frequency of IgM+ cells in B220+ splenocyte

decreased IgM level ( J:234285 )

• following immunization with the T cell-independent antigen NP28-aminoethyl carboxy-methyl-Ficoll (NP-Ficoll), mice exhibit a mild reduction in antigen-specific IgM compared with wild-type mice

cellular

enhanced autophagy ( J:234285 )

• increased autophagy in B cells

• however, Tg(BCL2)25Wehi expression reduces expression of the autophagy marker LC3

homeostasis/metabolism

increased cardiac muscle glycogen level ( J:234285 )

enhanced autophagy ( J:234285 )

• increased autophagy in B cells

• however, Tg(BCL2)25Wehi expression reduces expression of the autophagy marker LC3

muscle

increased cardiac muscle glycogen level ( J:234285 )

abnormal skeletal muscle morphology ( J:234285 )

• darker in color than in wild-type mice

hematopoietic system

impaired hematopoiesis ( J:234285 )

• mice exhibit a cell-intrinsic failure of hematopoietic precursors to repopulate the CD19+ compartment compared with wild-type mice

abnormal bone marrow cell number ( J:234285 )

• absence of IgM+ or IgD+ cells

• however, B220 low B cell precursors are present

decreased marginal zone B cell number ( J:234285 )

• reduced marginal zone B cells and marginal zone precursor compartments

• however, transitional and follicular B cell subsets are normal

absent B cells ( J:234285 )

• in the peritoneum and spleen

• Tg(BCL2)25Wehi expression or Trp53^tm1Tyj deficiency does not correct peripheral B cell numbers

abnormal splenocyte morphology ( J:234285 )

• reduced frequency of IgM+ cells in B220+ splenocyte

decreased IgM level ( J:234285 )

• following immunization with the T cell-independent antigen NP28-aminoethyl carboxy-methyl-Ficoll (NP-Ficoll), mice exhibit a mild reduction in antigen-specific IgM compared with wild-type mice

growth/size/body

enlarged heart ( J:234285 )

cardiac hypertrophy ( J:234285 )

Allelic Composition	Fnip1^m1Btlr/Fnip1^m1Btlr Prkag2^tm1.1Geno/Prkag2^tm1.1Geno Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
Genetic Background	involves: 129 * C57BL/6 * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3^{Tg(Sox2-cre)1Amc} mutation (5 available); any Edil3 mutation (42 available)
Fnip1^m1Btlr mutation (0 available); any Fnip1 mutation (59 available)
Prkag2^tm1.1Geno mutation (0 available); any Prkag2 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:256296 )

N	• mice exhibit rescue of the bradycardia seen in single Fnip1 homozygotes

Allelic Composition	Atg3^tm1.1Ywh/Atg3^tm1.1Ywh Fnip1^m1Btlr/Fnip1^m1Btlr Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg3^tm1.1Ywh mutation (0 available); any Atg3 mutation (19 available)
Fnip1^m1Btlr mutation (0 available); any Fnip1 mutation (59 available)
Gt(ROSA)26Sor^{tm1(cre/ERT)Nat} mutation (3 available); any Gt(ROSA)26Sor mutation (944 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

absent B cells ( J:234285 )

• in the spleen and bone marrow B cell subsets of tamoxifen-treated mice

cellular

abnormal autophagy ( J:234285 )

• tamoxifen-treated B cell precursors fail to exhibit an increase in bafilomycin-induced autophagy unlike in control cells

hematopoietic system

absent B cells ( J:234285 )

• in the spleen and bone marrow B cell subsets of tamoxifen-treated mice

homeostasis/metabolism

abnormal autophagy ( J:234285 )

• tamoxifen-treated B cell precursors fail to exhibit an increase in bafilomycin-induced autophagy unlike in control cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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