Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx3tm3Yg mutation
(0 available);
any
Runx3 mutation
(24 available)
Tg(Pou4f1-cre/ERT2)2Jiz mutation
(1 available)
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behavior/neurological
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• severely impaired gait pattern
• posterior placement of forelimbs and uncoordinated limb placement
• at 3 months of age only a small decrease in gait regularity is seen
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skeleton
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• mild scoliosis with about a 40% incidence
• bend is to the right of the coronal plane
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nervous system
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• decreased number of TrkC expressing proprioceptive neurons
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation
(2 available);
any
H2az2 mutation
(26 available)
Runx3tm3Yg mutation
(0 available);
any
Runx3 mutation
(24 available)
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behavior/neurological
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• severely impaired gait pattern
• posterior placement of forelimbs and uncoordinated limb placement
• at 3 months of age gait regularity is substantially decreased
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skeleton
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• more pronounced curvature compared to mice with Tg(Pou4f1-cre/ERT2)2Jiz mediated recombination with about a 75% incidence
• bend is to the right of the coronal plane
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nervous system
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• absence of TrkC expressing neurons
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx3tm3Yg mutation
(0 available);
any
Runx3 mutation
(24 available)
Tg(Col2a1-cre)1Bhr mutation
(3 available)
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growth/size/body
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• 2 of 7 mutants exhibit shorter stature
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skeleton
N |
• mice show no differences in bone development or structural parameters from wild-type mice
(J:224290)
• do not display scoliosis at 3 months of age
(J:243559)
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx3tm3Yg mutation
(0 available);
any
Runx3 mutation
(24 available)
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc mutation
(2 available)
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mortality/aging
growth/size/body
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• severe congenital dwarfism
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx3tm3Yg mutation
(0 available);
any
Runx3 mutation
(24 available)
Tg(Col1a1-cre)1Kry mutation
(2 available)
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growth/size/body
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• short stature that persists throughout life
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limbs/digits/tail
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• 21.7% lower bone thickness of 23 day old femurs
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• 25% smaller cortical area of 23 day old femurs
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skeleton
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• do not display scoliosis at 3 months of age
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• 21.7% lower bone thickness of 23 day old femurs
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• 25% smaller cortical area of 23 day old femurs
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• 27.1% reduction in bone mineral content in 23 day old femurs
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx2tm1Mjo mutation
(0 available);
any
Runx2 mutation
(42 available)
Runx3tm3Yg mutation
(0 available);
any
Runx3 mutation
(24 available)
Tg(Col1a1-cre)1Kry mutation
(2 available)
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx3tm3Yg mutation
(0 available);
any
Runx3 mutation
(24 available)
Tg(Scx-GFP)1Stzr mutation
(0 available)
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skeleton
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• do not display scoliosis at 3 months of age
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