Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Camk2atm1.1Yelg mutation
(0 available);
any
Camk2a mutation
(136 available)
Emx1tm1.1(cre)Ito mutation
(1 available);
any
Emx1 mutation
(34 available)
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behavior/neurological
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• mice show severe contextual fear learning deficits relative to control littermates, as revealed by a marked reduction in elicited freezing behavior
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• in the hidden version of the Morris water maze, mice search equally in all four quadrants with no clear preference for the target quadrant during the probe trial, and show a significant reduction in their latency time to reach the hidden platform at day 3, but not at the initial or final (day 5) training days relative to control littermates
• however, no significant differences in thigmotaxis, swim speed, or path length are observed
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Camk2atm1.1Yelg mutation
(0 available);
any
Camk2a mutation
(136 available)
Tg(CAG-cre/Esr1*)5Amc mutation
(9 available)
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behavior/neurological
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• adult mice treated with tamoxifen show severe contextual fear learning deficits relative to control littermates, as revealed by a marked reduction in elicited freezing behavior
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• in the hidden version of the Morris water maze, adult mice treated with tamoxifen search equally in all four quadrants with no clear preference for the target quadrant during the probe trial, unlike control littermates
• however, no significant differences in latency times to reach the hidden platform, thigmotaxis, swim speed, or path length are observed
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nervous system
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• adult mice treated with tamoxifen exhibit impaired synaptic plasticity
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• adult mice treated with tamoxifen show impaired LTP induction at the CA3-CA1 synapse in the hippocampus in two independent stimulation protocols (100 Hz and theta-burst) relative to control littermates
• however, basal synaptic transmission and paired-pulse facilitation (PPF) are normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Camk2atm1.1Yelg mutation
(0 available);
any
Camk2a mutation
(136 available)
Tg(Pcp2-cre)2Mpin mutation
(1 available)
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behavior/neurological
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N |
• at 2-5 months of age, mice exhibit normal spatial learning in the hidden version of the Morris water maze with a clear preference for the platform quadrant during the probe trial and a similar reduction in latency times during training relative to control littermates
• in addition, mice display intact contextual fear conditioning relative to control littermates
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Analysis Tools