Emx1tm1.1(cre)Ito
Targeted Allele Detail
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Symbol: |
Emx1tm1.1(cre)Ito |
Name: |
empty spiracles homeobox 1; targeted mutation 1.1, Shigeyoshi Itohara |
MGI ID: |
MGI:3762664 |
Synonyms: |
Emx1-Cre KI deltaneo, Emx1tm2(cre)Ito |
Gene: |
Emx1 Location: Chr6:85164913-85181445 bp, + strand Genetic Position: Chr6, 37.21 cM
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Alliance: |
Emx1tm1.1(cre)Ito page
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Germline Transmission: |
Earliest citation of germline transmission:
J:88421
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Parent Cell Line: |
E14 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Recombinase) |
Mutation: |
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Insertion
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Emx1tm1.1(cre)Ito expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Emx1 (MGI:95387) |
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Mutation details: A cDNA encoding Cre recombinase with an N-terminal nuclear localization signal (nls) resides immediately 5' of the translation initiation site of the endogenous gene. This allele was derived from Emx1tm1(cre)Ito by FLP recombinase excision of a FRT-flanked pgk-neo cassette that lay immediately downstream of the nls-cre gene. The Emx1 promoter drives Cre recombinase expression in the embryonic through adult dorsal telencephelon; deletion of the selection cassette reportedly prevents ectopic expression in other brain regions.
(J:64064, J:104881)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Emx1
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:88421 Iwasato T, et al., Dorsal telencephalon-specific expression of Cre recombinase in PAC transgenic mice. Genesis. 2004 Mar;38(3):130-8 |
All: |
51 reference(s) |
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