Camk2a^tm1.1Yelg
Targeted Allele Detail

Summary

• Symbol: Camk2a^tm1.1Yelg
• Name: calcium/calmodulin-dependent protein kinase II alpha; targeted mutation 1.1, Ype Elgersma
• MGI ID: MGI:5662417
• Synonyms: Camk2a^flox
• Gene: Camk2a Location: Chr18:61058704-61121224 bp, + strand Genetic Position: Chr18, 34.41 cM
• Alliance: Camk2a^tm1.1Yelg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:216169
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted 60 bp upstream of exon 2 and a floxed neo cassette was inserted approximately 1.2 kbp downstream of exon 2 via homologous recombination. Cre mediated recombination removed the neo cassette leaving exon 2 floxed. Western blot analysis revealed no detectable alteration of protein levels in the brain of homozygous mutant mice. (J:216169)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Camk2a Mutation: 136 strains or lines available

References

• Original: J:216169 Achterberg KG, et al., Temporal and region-specific requirements of alphaCaMKII in spatial and contextual learning. J Neurosci. 2014 Aug 20;34(34):11180-7
• All: 3 reference(s)