Phenotypes associated with this allele
Allelic
Composition |
Nlgn3tm4.1Sud/Y
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Genetic
Background |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn3tm4.1Sud mutation
(0 available);
any
Nlgn3 mutation
(35 available)
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behavior/neurological
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• mice injected with Ad-cre in the nucleus accumbens exhibit enhanced learning on the accelerating rotarod
• however, mice injected with Ad-cre in the dorsal striatum show normal performance on the rotarod
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• mice injected with Ad-cre in the nucleus accumbens exhibit increased open-field activity
• however, mice injected with Ad-cre in the dorsal striatum show normal performance in the open-field
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn3tm4.1Sud mutation
(0 available);
any
Nlgn3 mutation
(35 available)
Pvalbtm1(cre)Arbr mutation
(5 available);
any
Pvalb mutation
(29 available)
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behavior/neurological
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• mice exhibit decreased activity in the open field
• however, performance on the rotarod is normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn3tm4.1Sud mutation
(0 available);
any
Nlgn3 mutation
(35 available)
Tg(Drd1-cre)EY262Gsat mutation
(2 available)
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behavior/neurological
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• mice exhibit increased learning rate on the accelerating rotarod
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• mice exhibit increased open-field activity
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn1tm1.1Sud mutation
(0 available);
any
Nlgn1 mutation
(66 available)
Nlgn2tm1.1Sud mutation
(1 available);
any
Nlgn2 mutation
(34 available)
Nlgn3tm4.1Sud mutation
(0 available);
any
Nlgn3 mutation
(35 available)
Tg(Pcp2-cre)2Mpin mutation
(1 available)
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nervous system
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• 50% decrease in density of climbing fiber synapse on distal Purkinje cell dendrites
• 15% decrease in density of climbing fiber synapse on proximal Purkinje cell dendrites
• inhibitory basket/stellate cell synapses are increased in size, but not number
• 25% decrease in size of climbing fiber synapse on distal and proximal Purkinje cell dendrites
• increase in puncta density as detected by GAD65
• parallel fiber synapse density is not altered
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• decreased frequency of delayed quantal release events, but not amplitude events
• impaired synaptic transmission at GABAergic synapses
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• 40% decrease in amplitude of climbing fiber EPSCs in juvenile and adult mice
• however, no change in kinetics or paired pulse ratio of climbing fiber EPSCs and no alterations in parallel-fiber EPSCs
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• 80% decrease in IPSC amplitude in Purkinje cells, but no changes in kinetics or paired pulse ratio
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• 80% decrease in mIPSC frequency and amplitude (45%) in basket/stellate cell synapses
• decrease in decay, but not rise times of mIPSCs
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• 45% decrease in basket/stellate cell synapses
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• 80% decrease in basket/stellate cell synapses
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|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn1tm1.1Sud mutation
(0 available);
any
Nlgn1 mutation
(66 available)
Nlgn3tm4.1Sud mutation
(0 available);
any
Nlgn3 mutation
(35 available)
Tg(Pcp2-cre)2Mpin mutation
(1 available)
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nervous system
|
N |
• no change in parallel fiber synpatic transmission
• no change in basket/stellate cell synapse-mediated mIPSCs
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• 5% loss of distal climbing-fiber synapse numbers
• 25% decrease in synapse size
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• modest decrease (10%) in climbing fiber synapse EPSC amplitude
• no change in paired pulse ratio is detected or synapse elimination
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|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn3tm4.1Sud mutation
(0 available);
any
Nlgn3 mutation
(35 available)
Tg(Pcp2-cre)2Mpin mutation
(1 available)
|
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nervous system
|
N |
• no change in parallel fiber synpatic transmission
• no change in basket/stellate cell synapse-mediated mIPSCs
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• small decrease in climbing fiber synapse EPSC amplitude
• no change in paired pulse ratio is detected
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn2tm1.1Sud mutation
(1 available);
any
Nlgn2 mutation
(34 available)
Nlgn3tm4.1Sud mutation
(0 available);
any
Nlgn3 mutation
(35 available)
Tg(Pcp2-cre)2Mpin mutation
(1 available)
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nervous system
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N |
• no change in parallel fiber synpatic transmission
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• slight decrease in climbing-fiber synapse (vGluT2 staining) cluster density and size
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• decrease in climbing-fiber EPSC amplitude, but no change in quantal events
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• large decrease in frequency (90%) and amplitude (45%) of mIPScs
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn3tm4.1Sud mutation
(0 available);
any
Nlgn3 mutation
(35 available)
Tg(Adora2a-cre)2MDkde mutation
(0 available)
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behavior/neurological
|
N |
• mice exhibit normal behavior in the open-field and on the rotarod
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|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn3tm4.1Sud mutation
(0 available);
any
Nlgn3 mutation
(35 available)
Tg(Pcp2-cre)2Mpin mutation
(1 available)
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behavior/neurological
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• mice are hyperactive during open-field tests, showing increased total distance traveled and increased number of ambulatory episodes
• however, mice exhibit normal performance on the rotarod
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn3tm4.1Sud mutation
(0 available);
any
Nlgn3 mutation
(35 available)
Tg(Nes-cre)1Kln mutation
(4 available)
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behavior/neurological
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• mice are hyperactive during open-field tests, showing increased total distance traveled and increased number of ambulatory episodes
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Analysis Tools