Tg(Adora2a-cre)2MDkde
Transgene Detail
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Symbol: |
Tg(Adora2a-cre)2MDkde |
Name: |
transgene insertion 2M, Alban de Kerhcove d'Exaerde |
MGI ID: |
MGI:3852493 |
Synonyms: |
A2a-cre, Adora2a-cre |
Transgene: |
Tg(Adora2a-cre)2MDkde Location: unknown
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Alliance: |
Tg(Adora2a-cre)2MDkde page
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Transgene Type: |
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Transgenic (Recombinase) |
Mutation: |
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Insertion
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Tg(Adora2a-cre)2MDkde expression driven by
1 gene
Transgene expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Adora2a (MGI:99402) |
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Mutation details: A BAC clone of >160kb from a CJ7/129Sv Mouse BAC library (Invitrogen, formerly Genome Systems Inc.) containing the two exons of Adora2a, flanked by at least 70 kb of Adora2a 5' upstream sequences. This A2AR BAC was modified by homologous recombination in bacteria to replace the sequence of exon 1 (after the ATG transcription start site) with the cre recombinase coding sequence including 3 STOP codons. The purified BAC construct was injected into fertilized B6SJLF1 zygotes. Two founder lines, 2M and 9F, wer established. Mice were crossed to Rosa26-lacZ reporter mice to analyze cre-mediated recombination. Line 2M was used for further studies.
(J:150475)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Adora2a
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:150475 Durieux PF, et al., D2R striatopallidal neurons inhibit both locomotor and drug reward processes. Nat Neurosci. 2009 Apr;12(4):393-5 |
All: |
20 reference(s) |
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