Phenotypes associated with this allele

• Allele Symbol: Duoxa2^{tm1b(KOMP)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5637016
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Duoxa2^tm1b(KOMP)Wtsi/Duoxa2^tm1b(KOMP)Wtsi	C57BL/6N-Duoxa2^tm1b(KOMP)Wtsi/Wtsi	MGI:5785071

Genotype
MGI:5785071

hm1

• Allelic Composition: Duoxa2^{tm1b(KOMP)Wtsi}/Duoxa2^{tm1b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Duoxa2^{tm1b(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0899_5_A06

Data Sources

IMPC Data for Duoxa2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased total body fat amount ( J:211773 )

♂

IMPC - WTSI

increased total body fat amount ( J:211773 )

IMPC - WTSI

behavior/neurological

absent pinna reflex ( J:211773 )

IMPC - WTSI

decreased grip strength ( J:211773 )

IMPC - WTSI

cardiovascular system

decreased heart weight ( J:211773 )

IMPC - WTSI

craniofacial

abnormal cranium morphology ( J:211773 )

IMPC - WTSI

abnormal zygomatic bone morphology ( J:211773 )

IMPC - WTSI

abnormal snout morphology ( J:211773 )

IMPC - WTSI

growth/size/body

decreased lean body mass ( J:211773 )

IMPC - WTSI

increased lean body mass ( J:211773 )

IMPC - WTSI

abnormal head morphology ( J:211773 )

♂

IMPC - WTSI

abnormal zygomatic bone morphology ( J:211773 )

IMPC - WTSI

abnormal snout morphology ( J:211773 )

IMPC - WTSI

decreased body length ( J:211773 )

IMPC - WTSI

hearing/vestibular/ear

abnormal auditory brainstem response ( J:211773 )

IMPC - WTSI

hematopoietic system

decreased erythrocyte cell number ( J:211773 )

IMPC - WTSI

decreased hematocrit ( J:211773 )

♀

IMPC - WTSI

decreased hemoglobin content ( J:211773 )

♀

IMPC - WTSI

increased mean corpuscular hemoglobin ( J:211773 )

IMPC - WTSI

increased mean corpuscular hemoglobin concentration ( J:211773 )

♂

IMPC - WTSI

decreased red blood cell distribution width ( J:211773 )

IMPC - WTSI

increased neutrophil cell number ( J:211773 )

♀

IMPC - WTSI

decreased mean platelet volume ( J:211773 )

IMPC - WTSI

decreased CD11b-high dendritic cell number ( J:211773 )

IMPC - WTSI

increased plasmacytoid dendritic cell number ( J:211773 )

IMPC - WTSI

increased CD8-positive, naive alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased effector memory T-helper cell number ( J:211773 )

IMPC - WTSI

increased T cell number ( J:211773 )

IMPC - WTSI

increased alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased CD4-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

increased CD8-positive, alpha-beta T cell number ( J:211773 )

♂

IMPC - WTSI

increased effector memory CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased T-helper cell number ( J:211773 )

IMPC - WTSI

decreased leukocyte cell number ( J:211773 )

♂

IMPC - WTSI

decreased B cell number ( J:211773 )

IMPC - WTSI

decreased immature B cell number ( J:211773 )

IMPC - WTSI

decreased transitional stage T1 B cell number ( J:211773 )

IMPC - WTSI

decreased mature B cell number ( J:211773 )

IMPC - WTSI

decreased B-2 B cell number ( J:211773 )

IMPC - WTSI

decreased follicular B cell number ( J:211773 )

IMPC - WTSI

decreased NK cell number ( J:211773 )

♂

IMPC - WTSI

decreased KLRG1-positive NK cell number ( J:211773 )

IMPC - WTSI

decreased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

decreased CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased memory-marker gamma-delta T cell number ( J:211773 )

IMPC - WTSI

decreased Ly6C low monocyte number ( J:211773 )

IMPC - WTSI

homeostasis/metabolism

decreased circulating thyroxine level ( J:211773 )

IMPC - WTSI

increased circulating creatinine level ( J:211773 )

IMPC - WTSI

increased circulating fructosamine level ( J:211773 )

IMPC - WTSI

increased fasting circulating glucose level ( J:211773 )

IMPC - WTSI

decreased circulating glucose level ( J:211773 )

♂

IMPC - WTSI

increased circulating cholesterol level ( J:211773 )

IMPC - WTSI

increased circulating HDL cholesterol level ( J:211773 )

IMPC - WTSI

increased circulating LDL cholesterol level ( J:211773 )

IMPC - WTSI

increased circulating calcium level ( J:211773 )

IMPC - WTSI

increased circulating iron level ( J:211773 )

IMPC - WTSI

increased circulating sodium level ( J:211773 )

♀

IMPC - WTSI

decreased circulating amylase level ( J:211773 )

♂

IMPC - WTSI

increased circulating serum albumin level ( J:211773 )

IMPC - WTSI

increased circulating total protein level ( J:211773 )

IMPC - WTSI

increased blood urea nitrogen level ( J:211773 )

♂

IMPC - WTSI

improved glucose tolerance ( J:211773 )

♂

IMPC - WTSI

immune system

increased neutrophil cell number ( J:211773 )

♀

IMPC - WTSI

decreased CD11b-high dendritic cell number ( J:211773 )

IMPC - WTSI

increased plasmacytoid dendritic cell number ( J:211773 )

IMPC - WTSI

increased CD8-positive, naive alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased effector memory T-helper cell number ( J:211773 )

IMPC - WTSI

increased T cell number ( J:211773 )

IMPC - WTSI

increased alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased CD4-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

increased CD8-positive, alpha-beta T cell number ( J:211773 )

♂

IMPC - WTSI

increased effector memory CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased T-helper cell number ( J:211773 )

IMPC - WTSI

decreased leukocyte cell number ( J:211773 )

♂

IMPC - WTSI

decreased B cell number ( J:211773 )

IMPC - WTSI

decreased immature B cell number ( J:211773 )

IMPC - WTSI

decreased transitional stage T1 B cell number ( J:211773 )

IMPC - WTSI

decreased mature B cell number ( J:211773 )

IMPC - WTSI

decreased B-2 B cell number ( J:211773 )

IMPC - WTSI

decreased follicular B cell number ( J:211773 )

IMPC - WTSI

decreased NK cell number ( J:211773 )

♂

IMPC - WTSI

decreased KLRG1-positive NK cell number ( J:211773 )

IMPC - WTSI

decreased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

decreased CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased memory-marker gamma-delta T cell number ( J:211773 )

IMPC - WTSI

decreased Ly6C low monocyte number ( J:211773 )

IMPC - WTSI

integument

abnormal hair growth ( J:211773 )

IMPC - WTSI

limbs/digits/tail

abnormal humerus morphology ( J:211773 )

IMPC - WTSI

abnormal radius morphology ( J:211773 )

IMPC - WTSI

abnormal ulna morphology ( J:211773 )

IMPC - WTSI

abnormal femur morphology ( J:211773 )

IMPC - WTSI

abnormal tibia morphology ( J:211773 )

IMPC - WTSI

normal phenotype

no abnormal phenotype detected ( J:239583 )

DMDD

skeleton

abnormal cranium morphology ( J:211773 )

IMPC - WTSI

abnormal zygomatic bone morphology ( J:211773 )

IMPC - WTSI

abnormal humerus morphology ( J:211773 )

IMPC - WTSI

abnormal radius morphology ( J:211773 )

IMPC - WTSI

abnormal ulna morphology ( J:211773 )

IMPC - WTSI

abnormal femur morphology ( J:211773 )

IMPC - WTSI

abnormal tibia morphology ( J:211773 )

IMPC - WTSI

abnormal clavicle morphology ( J:211773 )

IMPC - WTSI

abnormal thoracic cage shape ( J:211773 )

IMPC - WTSI

abnormal vertebrae morphology ( J:211773 )

IMPC - WTSI

abnormal vertebral arch morphology ( J:211773 )

IMPC - WTSI

abnormal bone structure ( J:211773 )

♀

IMPC - WTSI

decreased bone mineral content ( J:211773 )

IMPC - WTSI

decreased bone mineral density ( J:211773 )

♀

IMPC - WTSI

abnormal joint morphology ( J:211773 )

IMPC - WTSI

vision/eye

abnormal iris morphology ( J:211773 )

IMPC - WTSI

abnormal eyelid morphology ( J:211773 )

♀

IMPC - WTSI