All Phenotypes Adamts9<tm1.2Apte> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Adamts9^tm1.2Apte
targeted mutation 1.2, Suneel Apte
MGI:5603304

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adamts9^tm1.2Apte/Adamts9^tm1.2Apte	involves: 129S4/SvJae * C57BL/6 * SJL	MGI:5603307
hm2	Adamts9^tm1.2Apte/Adamts9^tm1.2Apte	involves: C57BL/6J * C57BL/6NTac	MGI:5812911
ht3	Adamts9^tm1.2Apte/Adamts9⁺	involves: 129S4/SvJae * C57BL/6 * SJL	MGI:5603306
ht4	Adamts9^tm1Dgen/Adamts9^tm1.2Apte	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL	MGI:5603308
cn5	Adamts9^tm1.1Apte/Adamts9^tm1.2Apte Tg(Prrx1-cre)1Cjt/0	involves: 129S4/SvJae * C57BL/6 * SJL	MGI:5603310
cx6	Adamts20^bt-Bei1/Adamts20^bt-Bei1 Adamts9^tm1.2Apte/Adamts9⁺	involves: 129S4/SvJae * C57BL/6 * SJL	MGI:5603312
cx7	Adamts9^tm1.2Apte/Adamts9⁺ B3glct^tm1.2Nari/B3glct^tm1.2Nari	involves: 129S4/SvJaeSor * C57BL/6J * C57BL/6NTac * DBA/2 * SJL	MGI:6407447

Allelic Composition	Adamts9^tm1.2Apte/Adamts9^tm1.2Apte
Genetic Background	involves: 129S4/SvJae * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts9^tm1.2Apte mutation (1 available); any Adamts9 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:213412 )

• embryos are small and malformed by E7.5

Allelic Composition	Adamts9^tm1.2Apte/Adamts9^tm1.2Apte
Genetic Background	involves: C57BL/6J * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts9^tm1.2Apte mutation (1 available); any Adamts9 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal gastrulation ( J:234992 )

abnormal embryo morphology ( J:234992 )

• embryos appear compressed

• embryos appear constricted proximal to the epiblast

abnormal embryonic epiblast morphology ( J:234992 )

• in some E7.5 embryos the epiblast is separated from the extraembryonic ectoderm by the parietal endoderm layer

absent mesoderm ( J:234992 )

• E7.5 embryos lack mesoderm

disorganized embryonic tissue ( J:234992 )

disorganized extraembryonic tissue ( J:234992 )

abnormal visceral endoderm morphology ( J:234992 )

• visceral endoderm is highly folded and lacks apical vacuoles

Allelic Composition	Adamts9^tm1.2Apte/Adamts9⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts9^tm1.2Apte mutation (1 available); any Adamts9 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal heart valve morphology ( J:213412 )

• cardiac valve abnormalities

limbs/digits/tail

limbs/digits/tail phenotype ( J:213412 )

N	• soft tissue syndactly is not observed

vision/eye

abnormal eye morphology ( J:213412 )

• eye defects

Allelic Composition	Adamts9^tm1Dgen/Adamts9^tm1.2Apte
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts9^tm1.2Apte mutation (1 available); any Adamts9 mutation (90 available)
Adamts9^tm1Dgen mutation (0 available); any Adamts9 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:213412 )

• no viable embryos are identified at E9.5

Allelic Composition	Adamts9^tm1.1Apte/Adamts9^tm1.2Apte Tg(Prrx1-cre)1Cjt/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts9^tm1.1Apte mutation (1 available); any Adamts9 mutation (90 available)
Adamts9^tm1.2Apte mutation (1 available); any Adamts9 mutation (90 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

syndactyly ( J:213412 )

• present in all forelimbs and all hindlimbs

• mice do not have structural anomalies of bone or patterning anomalies

interdigital webbing ( J:213412 )

• webs are present in all interdigits, although webs do not extend to the tips of digits

Allelic Composition	Adamts20^bt-Bei1/Adamts20^bt-Bei1 Adamts9^tm1.2Apte/Adamts9⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts20^bt-Bei1 mutation (0 available); any Adamts20 mutation (93 available)
Adamts9^tm1.2Apte mutation (1 available); any Adamts9 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

cleft secondary palate ( J:213412 )

• complete cleft of the secondary palate

• cleft palate is 100% penetrant

digestive/alimentary system

cleft secondary palate ( J:213412 )

• complete cleft of the secondary palate

• cleft palate is 100% penetrant

embryo

abnormal melanoblast morphology ( J:213412 )

• reduced numbers of melanoblasts in hair follicles

growth/size/body

cleft secondary palate ( J:213412 )

• complete cleft of the secondary palate

• cleft palate is 100% penetrant

integument

abnormal hair follicle melanin granule morphology ( J:213412 )

• hair follicles are unpigmented or have low pigment levels

absent hair follicle melanin granules ( J:213412 )

• hair follicles are unpigmented or have low pigment levels

limbs/digits/tail

syndactyly ( J:213412 )

• soft tissue syndactly

nervous system

abnormal melanoblast morphology ( J:213412 )

• reduced numbers of melanoblasts in hair follicles

pigmentation

abnormal hair follicle melanin granule morphology ( J:213412 )

• hair follicles are unpigmented or have low pigment levels

absent hair follicle melanin granules ( J:213412 )

• hair follicles are unpigmented or have low pigment levels

Allelic Composition	Adamts9^tm1.2Apte/Adamts9⁺ B3glct^tm1.2Nari/B3glct^tm1.2Nari
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6J * C57BL/6NTac * DBA/2 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts9^tm1.2Apte mutation (1 available); any Adamts9 mutation (90 available)
B3glct^tm1.2Nari mutation (0 available); any B3glct mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:286130 )

craniofacial

cleft palate ( J:286130 )

• 100% penetrance of cleft palate

digestive/alimentary system

cleft palate ( J:286130 )

• 100% penetrance of cleft palate

growth/size/body

cleft palate ( J:286130 )

• 100% penetrance of cleft palate

vision/eye

abnormal eye morphology ( J:286130 )

• late gestation embryos show eye abnormalities ranging from small eye and/or pupil to absent pupil and/or eye

microphthalmia ( J:286130 )

• small eyes in some mutants

anophthalmia ( J:286130 )

• eyes are absent is some mutants

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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