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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dcbld2tm1.1Mhms
targeted mutation 1.1, Mehran M Sadeghi
MGI:5569304
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dcbld2tm1.1Mhms/Dcbld2tm1.1Mhms B6.129S6-Dcbld2tm1.1Mhms MGI:5569329
cn2
 		Dcbld2tm1Mhms/Dcbld2tm1.1Mhms
Tg(Cdh5-cre)7Mlia/0 		involves: 129S6/SvEvTac * C57BL/6J * FVB/N MGI:5569330


Genotype
MGI:5569329
hm1
Allelic
Composition		 Dcbld2tm1.1Mhms/Dcbld2tm1.1Mhms
Genetic
Background		 B6.129S6-Dcbld2tm1.1Mhms
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dcbld2tm1.1Mhms mutation (0 available); any Dcbld2 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Attenuation of adult angiogenesis following left femoral artery ligation in Dcbld2tm1.1Mhms/Dcbld2tm1.1Mhms mice

cardiovascular system
abnormal retina vasculature morphology ( J:207629 )
• at P5, retinal blood vessels exhibit reduced total length and number of branches compared to in wild-type mice
abnormal pericyte morphology ( J:207629 )
• reduced pericyte staining
decreased angiogenesis ( J:207629 )
• at P5, retinal blood vessels exhibit reduced total length and number of branches compared to in wild-type mice
• reduced increase in capillary density of adult mice following femoral artery ligation
abnormal blood flow velocity ( J:207629 )
• impaired blood flow recovery following femoral artery ligation

respiratory system

vision/eye
abnormal retina vasculature morphology ( J:207629 )
• at P5, retinal blood vessels exhibit reduced total length and number of branches compared to in wild-type mice

cellular




Genotype
MGI:5569330
cn2
Allelic
Composition		 Dcbld2tm1Mhms/Dcbld2tm1.1Mhms
Tg(Cdh5-cre)7Mlia/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dcbld2tm1.1Mhms mutation (0 available); any Dcbld2 mutation (47 available)
Dcbld2tm1Mhms mutation (0 available); any Dcbld2 mutation (47 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Decreased retinal angiogenesis in Dcbld2tm1Mhms/Dcbld2tm1.1Mhms Tg(Cdh5-cre)7Mlia/0 mice

cardiovascular system
abnormal retina vasculature morphology ( J:207629 )
• at P5, retinal blood vessels exhibit reduced total length and number of branches compared to in wild-type mice
abnormal pericyte morphology ( J:207629 )
• reduced pericyte staining
decreased angiogenesis ( J:207629 )
• at P5, retinal blood vessels exhibit reduced total length and number of branches compared to in wild-type mice

vision/eye
abnormal retina vasculature morphology ( J:207629 )
• at P5, retinal blood vessels exhibit reduced total length and number of branches compared to in wild-type mice




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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory