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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mef2atm1.1Limm
targeted mutation 1.1, Lisa Monteggia
MGI:5560553
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mef2atm1.1Limm/Mef2atm1.1Limm involves: 129S/SvEv * C57BL/6 MGI:5560661
cn2
 		Mef2atm1.1Limm/Mef2atm1.1Limm
Mef2ctm1Jjs/Mef2ctm1Jjs
Tg(Cdh5-cre/ERT2)1Rha/0 		involves: 129S/SvEv * 129S6/SvEvTac MGI:7447283
cn3
 		Mef2atm1.1Limm/Mef2atm1.1Limm
Mef2ctm2Eno/Mef2ctm2Eno
Mef2dtm3Eno/Mef2dtm3Eno
Tg(GFAP-cre)25Mes/0 		involves: 129S/SvEv * C57BL/6 * FVB/N MGI:5560657
cn4
 		Mef2atm1.1Limm/Mef2atm1.1Limm
Mef2dtm3Eno/Mef2dtm3Eno
Tg(GFAP-cre)25Mes/0 		involves: 129S/SvEv * C57BL/6 * FVB/N MGI:5560659
cn5
 		Mef2atm1.1Limm/Mef2atm1.1Limm
Tg(GFAP-cre)25Mes/0 		involves: 129S/SvEv * C57BL/6 * FVB/N MGI:5560660


Genotype
MGI:5560661
hm1
Allelic
Composition		 Mef2atm1.1Limm/Mef2atm1.1Limm
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mef2atm1.1Limm mutation (0 available); any Mef2a mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:207812 )
• mice exhibit no apparent abnormalities




Genotype
MGI:7447283
cn2
Allelic
Composition		 Mef2atm1.1Limm/Mef2atm1.1Limm
Mef2ctm1Jjs/Mef2ctm1Jjs
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background		 involves: 129S/SvEv * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mef2atm1.1Limm mutation (0 available); any Mef2a mutation (36 available)
Mef2ctm1Jjs mutation (1 available); any Mef2c mutation (33 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal retina vasculature morphology ( J:334208 )
• reduced sprouting angiogenesis in retina at age P5 (4 days after endothelial-cell-specific KO induction): reduced vascular density and coverage in vascular plexus and reduced number of tip cells at angiogenic front
decreased angiogenesis ( J:334208 )
• reduced sprouting angiogenesis in retina at age P5 (4 days after endothelial-cell-specific KO induction): reduced vascular density and coverage in vascular plexus and reduced number of tip cells at angiogenic front

vision/eye
abnormal retina vasculature morphology ( J:334208 )
• reduced sprouting angiogenesis in retina at age P5 (4 days after endothelial-cell-specific KO induction): reduced vascular density and coverage in vascular plexus and reduced number of tip cells at angiogenic front




Genotype
MGI:5560657
cn3
Allelic
Composition		 Mef2atm1.1Limm/Mef2atm1.1Limm
Mef2ctm2Eno/Mef2ctm2Eno
Mef2dtm3Eno/Mef2dtm3Eno
Tg(GFAP-cre)25Mes/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mef2atm1.1Limm mutation (0 available); any Mef2a mutation (36 available)
Mef2ctm2Eno mutation (0 available); any Mef2c mutation (33 available)
Mef2dtm3Eno mutation (0 available); any Mef2d mutation (64 available)
Tg(GFAP-cre)25Mes mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:207812 )
• partial lethality by 5 weeks

nervous system
nervous system phenotype ( J:207812 )
N
• mice exhibit normal numbers of spines per length of dendrite in pyramidal neurons
abnormal long-term potentiation ( J:207812 )
• mice exhibit decreased input-output curve compared with wild-type mice
• however, long term potentiation is normal

growth/size/body
decreased body weight ( J:207812 )

cellular




Genotype
MGI:5560659
cn4
Allelic
Composition		 Mef2atm1.1Limm/Mef2atm1.1Limm
Mef2dtm3Eno/Mef2dtm3Eno
Tg(GFAP-cre)25Mes/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mef2atm1.1Limm mutation (0 available); any Mef2a mutation (36 available)
Mef2dtm3Eno mutation (0 available); any Mef2d mutation (64 available)
Tg(GFAP-cre)25Mes mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:207812 )
N
• mice exhibit normal learning and memory in context- and cue-dependent fear conditioning tests, normal anxiety-related behaviors and pain sensitivity
impaired coordination ( J:207812 )
• on a rotarod

nervous system
nervous system phenotype ( J:207812 )
N
• mice exhibit normal synapse number and basal synaptic transmission




Genotype
MGI:5560660
cn5
Allelic
Composition		 Mef2atm1.1Limm/Mef2atm1.1Limm
Tg(GFAP-cre)25Mes/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mef2atm1.1Limm mutation (0 available); any Mef2a mutation (36 available)
Tg(GFAP-cre)25Mes mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:207812 )
N
• mice exhibit normal behavior




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory