About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tet1tm1Gxu
targeted mutation 1, Guo-Liang Xu
MGI:5523868
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tet1tm1Gxu/Tet1tm1Gxu involves: 129 * C57BL/6J MGI:5523876
cn2
 		Tet1tm1Gxu/Tet1tm1.1Gxu
Tg(Nes-cre/ERT2)KEisc/0 		involves: 129 * C57BL/6J MGI:5523877


Genotype
MGI:5523876
cn1
Allelic
Composition		 Tet1tm1Gxu/Tet1tm1Gxu
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tet1tm1Gxu mutation (0 available); any Tet1 mutation (142 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuronal precursor proliferation ( J:201001 )
• adult neural progenitor cells transfected with a cre-expressing adenovirus exhibit reduced neurosphere growth in culture compared with control cells

cellular
abnormal neuronal precursor proliferation ( J:201001 )
• adult neural progenitor cells transfected with a cre-expressing adenovirus exhibit reduced neurosphere growth in culture compared with control cells




Genotype
MGI:5523877
cn2
Allelic
Composition		 Tet1tm1Gxu/Tet1tm1.1Gxu
Tg(Nes-cre/ERT2)KEisc/0
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tet1tm1.1Gxu mutation (0 available); any Tet1 mutation (142 available)
Tet1tm1Gxu mutation (0 available); any Tet1 mutation (142 available)
Tg(Nes-cre/ERT2)KEisc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuron differentiation ( J:201001 )
• mice treated with tamoxifen at 2 months of age exhibit impaired adult neurogenesis compared with control mice
abnormal neuronal precursor proliferation ( J:201001 )
• mice treated with tamoxifen at 2 months of age exhibit decreased proliferation of intermediate progenitor cells in the dentate gyrus compared with control mice

cellular
abnormal neuron differentiation ( J:201001 )
• mice treated with tamoxifen at 2 months of age exhibit impaired adult neurogenesis compared with control mice
abnormal neuronal precursor proliferation ( J:201001 )
• mice treated with tamoxifen at 2 months of age exhibit decreased proliferation of intermediate progenitor cells in the dentate gyrus compared with control mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory