hematopoietic system
Allele Symbol Allele Name Allele ID |
Kdm1atm1.1Sho targeted mutation 1.1, Stuart Orkin MGI:5514399 |
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Summary |
5 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• embryos are smaller than control at E13.5
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• embryos are smaller than control at E13.5
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• 300% increase in CD71hi Ter119low proerythroblasts found in fetal liver cells
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• 20-fold decrease in number of erythrocytes found in fetal (E13.5) liver cells
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• 20-fold decrease in number of reticulocytes found in fetal (E13.5) liver cells
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• E13.5 livers exhibit a disturbed architecture with multiple pyknotic cells displaying karyorrhexis
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• fetal liver (E13.5) is pale
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• hematopoietic stem and progenitor cell populations are distorted
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• 30 fold decrease in numbers of myeloid progenitors (Sca-1- cKit+, LS-K+)
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• found in femur and tibia of 5 day old mice as compared to control
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• found in peripheral blood of 5 day old mice as compared to control
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• found in peripheral blood of 5 day old mice as compared to control
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• found in peripheral blood of 5 day old mice as compared to control
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• 30 fold decrease in numbers of hematopoietic stem cells and multipotent progenitors (Sca-1+ cKit+, LS+K+)
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• found in peripheral blood of 5 day old mice as compared to control
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• newborn pups are smaller than controls
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• lethality is a result severe anemia
• most mice die by day 10
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• most mice die 7-10 days after final dose of the immunostimulant dsRNA poly(I:C) as compared to controls
• lethality is a result severe anemia
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• hematopoietic stem and progenitor cell populations are distorted following final dose of poly(I:C)
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• increase in numbers of bipotential granulocytic/moncytic precursor cells following final dose of poly(I:C)
• accumulation of immature myeloid cells
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• decrease in numbers of myeloid progenitors (Sca-1- cKit+, LS-K+) after final dose of poly(I:C)
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• Gr1high Mac1+ granulocytes are almost absent from bone marrow after final dose of poly(I:C)
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• loss of mature neutrophils following final dose of poly(I:C)
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• decrease in numbers of hematopoietic stem cells and multipotent progenitors (Sca-1+ cKit+, LS+K+) 1 week after final dose of poly(I:C)
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• following final dose of poly(I:C)
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• four fold increase in long term repopulating hematopoietic stem cell (LT-HSC) population (lin- CD150+ CD48- Sca-1+ c-Kit+) found in recombined cells
• immunophenotypic LT-HSC population exhibits 2-fold proliferation, but unaltered apoptosis levels
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• Gr1high Mac1+ granulocytes are almost absent from bone marrow after final dose of poly(I:C)
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• loss of mature neutrophils following final dose of poly(I:C)
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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