Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm2(Pik3ca*)Dsa}
• Allele Name: targeted mutation 2, Dieter Saur
• Allele ID: MGI:5510667
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm2(Pik3ca*)Dsa/Gt(ROSA)26Sor^+ Kras^tm4Tyj/Kras^+ Pdpk1^tm1Mlw/Pdpk1^tm1Mlw Ptf1a^tm1(cre)Hnak/Ptf1a^+	involves: 129S4/SvJae * 129S6/SvEvTac	MGI:5510696
cn2	Gt(ROSA)26Sor^tm2(Pik3ca*)Dsa/Gt(ROSA)26Sor^+ Ptf1a^tm1(cre)Hnak/Ptf1a^+	involves: 129S6/SvEvTac	MGI:5510694
cn3	Gt(ROSA)26Sor^tm2(Pik3ca*)Dsa/Gt(ROSA)26Sor^+ Pdpk1^tm1Mlw/Pdpk1^tm1Mlw Ptf1a^tm1(cre)Hnak/Ptf1a^+	involves: 129S6/SvEvTac	MGI:5510695
cn4	Gt(ROSA)26Sor^tm2(Pik3ca*)Dsa/Gt(ROSA)26Sor^+ Tg(Cela1-cre/ERT)1Dam/0	involves: 129S6/SvEvTac	MGI:5510697

Genotype
MGI:5510696

cn1

• Allelic Composition: Gt(ROSA)26Sor^{tm2(Pik3ca*)Dsa}/Gt(ROSA)26Sor⁺; Kras^tm4Tyj/Kras⁺; Pdpk1^tm1Mlw/Pdpk1^tm1Mlw; Ptf1a^tm1(cre)Hnak/Ptf1a⁺
• Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:197054 )

N • mice do not develop acinar to ductal metaplasia

neoplasm

neoplasm ( J:197054 )

N • mice do not develop pancreatic intraepithelial neoplasia or pancreatic ductal adenocarcinoma

Genotype
MGI:5510694

cn2

• Allelic Composition: Gt(ROSA)26Sor^{tm2(Pik3ca*)Dsa}/Gt(ROSA)26Sor⁺; Ptf1a^tm1(cre)Hnak/Ptf1a⁺
• Genetic Background: involves: 129S6/SvEvTac

endocrine/exocrine glands

enlarged pancreas ( J:197054 )

increased pancreas weight ( J:197054 )

pancreatic acinar-to-ductal metaplasia ( J:197054 )

• massive induction of acinar to ductal metaplasia

increased pancreatic ductal adenocarcinoma incidence ( J:197054 )

• phenocopies metastatic pancreatic ductal adenocarcinoma that develops in mice expressing with Kras^tm4Tyj activated in the pancreas

increased pancreatic intraepithelial neoplasia incidence ( J:197054 )

• in all mice as early as 1 month with progression in amount and grade over time

neoplasm

increased pancreatic intraepithelial neoplasia incidence ( J:197054 )

• in all mice as early as 1 month with progression in amount and grade over time

increased carcinoma incidence ( J:197054 )

• pancreatic carcinoma in situ in some mice at 9 months

increased pancreatic ductal adenocarcinoma incidence ( J:197054 )

• phenocopies metastatic pancreatic ductal adenocarcinoma that develops in mice expressing with Kras^tm4Tyj activated in the pancreas

growth/size/body

enlarged pancreas ( J:197054 )

increased pancreas weight ( J:197054 )

Genotype
MGI:5510695

cn3

• Allelic Composition: Gt(ROSA)26Sor^{tm2(Pik3ca*)Dsa}/Gt(ROSA)26Sor⁺; Pdpk1^tm1Mlw/Pdpk1^tm1Mlw; Ptf1a^tm1(cre)Hnak/Ptf1a⁺
• Genetic Background: involves: 129S6/SvEvTac

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:197054 )

N • mice do not develop acinar to ductal metaplasia

neoplasm

neoplasm ( J:197054 )

N • mice do not develop pancreatic intraepithelial neoplasia or pancreatic ductal adenocarcinoma

Genotype
MGI:5510697

cn4

• Allelic Composition: Gt(ROSA)26Sor^{tm2(Pik3ca*)Dsa}/Gt(ROSA)26Sor⁺; Tg(Cela1-cre/ERT)1Dam/0
• Genetic Background: involves: 129S6/SvEvTac

endocrine/exocrine glands

pancreatic acinar-to-ductal metaplasia ( J:197054 )

• induction of acinar to ductal metaplasia

increased pancreatic intraepithelial neoplasia incidence ( J:197054 )

neoplasm

increased pancreatic intraepithelial neoplasia incidence ( J:197054 )