All Phenotypes Gt(ROSA)26Sor<tm2(Pik3ca*)Dsa> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gt(ROSA)26Sor^{tm2(Pik3ca*)Dsa}
targeted mutation 2, Dieter Saur
MGI:5510667

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^{tm2(Pik3ca*)Dsa}/Gt(ROSA)26Sor⁺ Kras^tm4Tyj/Kras⁺ Pdpk1^tm1Mlw/Pdpk1^tm1Mlw Ptf1a^tm1(cre)Hnak/Ptf1a⁺	involves: 129S4/SvJae * 129S6/SvEvTac	MGI:5510696
cn2	Gt(ROSA)26Sor^{tm2(Pik3ca*)Dsa}/Gt(ROSA)26Sor⁺ Ptf1a^tm1(cre)Hnak/Ptf1a⁺	involves: 129S6/SvEvTac	MGI:5510694
cn3	Gt(ROSA)26Sor^{tm2(Pik3ca*)Dsa}/Gt(ROSA)26Sor⁺ Pdpk1^tm1Mlw/Pdpk1^tm1Mlw Ptf1a^tm1(cre)Hnak/Ptf1a⁺	involves: 129S6/SvEvTac	MGI:5510695
cn4	Gt(ROSA)26Sor^{tm2(Pik3ca*)Dsa}/Gt(ROSA)26Sor⁺ Tg(Cela1-cre/ERT)1Dam/0	involves: 129S6/SvEvTac	MGI:5510697

Allelic Composition	Gt(ROSA)26Sor^{tm2(Pik3ca*)Dsa}/Gt(ROSA)26Sor⁺ Kras^tm4Tyj/Kras⁺ Pdpk1^tm1Mlw/Pdpk1^tm1Mlw Ptf1a^tm1(cre)Hnak/Ptf1a⁺
Genetic Background	involves: 129S4/SvJae * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm2(Pik3ca*)Dsa} mutation (0 available); any Gt(ROSA)26Sor mutation (1046 available)
Kras^tm4Tyj mutation (11 available); any Kras mutation (69 available)
Pdpk1^tm1Mlw mutation (0 available); any Pdpk1 mutation (141 available)
Ptf1a^tm1(cre)Hnak mutation (1 available); any Ptf1a mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:197054 )

N	• mice do not develop acinar to ductal metaplasia

neoplasm

neoplasm ( J:197054 )

N	• mice do not develop pancreatic intraepithelial neoplasia or pancreatic ductal adenocarcinoma

Allelic Composition	Gt(ROSA)26Sor^{tm2(Pik3ca*)Dsa}/Gt(ROSA)26Sor⁺ Ptf1a^tm1(cre)Hnak/Ptf1a⁺
Genetic Background	involves: 129S6/SvEvTac

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

enlarged pancreas ( J:197054 )

increased pancreas weight ( J:197054 )

increased pancreatic ductal adenocarcinoma incidence ( J:197054 )

• phenocopies metastatic pancreatic ductal adenocarcinoma that develops in mice expressing with Kras^tm4Tyj activated in the pancreas

increased pancreatic intraepithelial neoplasia incidence ( J:197054 )

• in all mice as early as 1 month with progression in amount and grade over time

pancreatic acinar-to-ductal metaplasia ( J:197054 )

• massive induction of acinar to ductal metaplasia

neoplasm

increased pancreatic intraepithelial neoplasia incidence ( J:197054 )

• in all mice as early as 1 month with progression in amount and grade over time

increased carcinoma incidence ( J:197054 )

• pancreatic carcinoma in situ in some mice at 9 months

increased pancreatic ductal adenocarcinoma incidence ( J:197054 )

• phenocopies metastatic pancreatic ductal adenocarcinoma that develops in mice expressing with Kras^tm4Tyj activated in the pancreas

growth/size/body

enlarged pancreas ( J:197054 )

increased pancreas weight ( J:197054 )

Allelic Composition	Gt(ROSA)26Sor^{tm2(Pik3ca*)Dsa}/Gt(ROSA)26Sor⁺ Pdpk1^tm1Mlw/Pdpk1^tm1Mlw Ptf1a^tm1(cre)Hnak/Ptf1a⁺
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm2(Pik3ca*)Dsa} mutation (0 available); any Gt(ROSA)26Sor mutation (1046 available)
Pdpk1^tm1Mlw mutation (0 available); any Pdpk1 mutation (141 available)
Ptf1a^tm1(cre)Hnak mutation (1 available); any Ptf1a mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:197054 )

N	• mice do not develop acinar to ductal metaplasia

neoplasm

neoplasm ( J:197054 )

N	• mice do not develop pancreatic intraepithelial neoplasia or pancreatic ductal adenocarcinoma

Allelic Composition	Gt(ROSA)26Sor^{tm2(Pik3ca*)Dsa}/Gt(ROSA)26Sor⁺ Tg(Cela1-cre/ERT)1Dam/0
Genetic Background	involves: 129S6/SvEvTac

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased pancreatic intraepithelial neoplasia incidence ( J:197054 )

pancreatic acinar-to-ductal metaplasia ( J:197054 )

• induction of acinar to ductal metaplasia

neoplasm

increased pancreatic intraepithelial neoplasia incidence ( J:197054 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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